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Category: Volume 05 Issue 07 July 2017
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Title: Effect of Age on Estimated Glomerular Filtration Rate

Author: Pallavi Mahajan

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.251

Abstract

Glomerular filtration rate is the best determinant for the evaluation of renal function. It is important for the differentiation of various kidney diseases, for the evaluation of the effect and dose adjustment of various drugs. For the estimation of GFR precise methods and appropriate reference values are to be used and it is often estimated from equations that include variables like age, sex, race, creatinine and cystatin C. In the earlier studies, the variable results of the effects of age and sex on renal function were observed. So, the present study was conducted to estimate and compare the eGFR both creatinine and cystatin C based in apparently healthy subjects of different age groups. It was observed that there was decline in estimated GFR in both creatinine and cystatin based with increase in the age in both the genders. Hence, depending on the equation used for the estimation of GFR, the reference range adjusted for different age groups should be taken into consideration.

Keywords: Glomerular filtration rate, age, sex, eGFR

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Corresponding Author

Dr Pallavi Mahajan

Demonstrator, Department of Biochemistry, Government Medical College, Jammu, J&K

Phone no. 9419114012, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.