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Category: Volume 05 Issue 07 July 2017
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Title: Glutathione-S-Transferase and GST-π in Gastric Carcinoma

Authors: Dr Subhasis Mandal, Dr Meenakshi Kekre, Dr Karansingh Chandrakar

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.233

Abstract

Aims: To analyze the level of serum Glutathione-S-Transferase (GST) and Glutathione-S-Transferase pi (GST π) before and after Cycles Of chemotherapy in patients suffering from gastric carcinoma.

Methods: For the study comprising total 30 cases suffering from gastric carcinoma before and after chemotherapy were selected. All patients were clinically and histologically diagnosed. A total of 50 age and sex matched healthy subjects taken as control. The circulating levels of GST and GST π activity were assayed in the in the serum of control group and in patients with gastric carcinoma.

Results: Mean GST and GST π activity in serum were significantly higher in gastric carcinoma patients as compared to control (p<0.001). After chemotherapy the activity of GST and GST π were significantly higher than before chemotherapy. It indicated that plasma GST and GST-π also may be useful in diagnosing and monitoring gastric carcinoma. The generation of free radicals as reflected by increased GST and GST-π activity in carcinoma cases.

Conclusion: In the gastric carcinoma, increased activity of GST and GST Pi isoenzyme was significant as that of the tissue content, the fact that higher serum values of patients with some cancers often reverted to the normal range after treatment of the gastric carcinoma suggested the direct derivation of these enzymes from tumor tissues. Thus, follow up of elevated serum GST and GST Pi levels may be useful for monitoring gastric carcinoma patients during the course of treatment. Our results indicated that plasma GST-π also may be useful in diagnosing gastrointestinal cancer.      

Keywords: Cisplastin, capecitabine, stomach cancer, tumor marker, chemotherapy, Glutathione-s-transferase, GST π, ROS, GIT and radiotherapy.

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Corresponding Author

Dr Karansingh Chandrakar

Assistant Professor Dept. of Pathology, CCM Medical College Kachandur, Durg Chhattisgarh 490024

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