Title: Evaluation of Serum Electrolytes, Urea and Creatinine Levels in HIV – Positive Patients in Makurdi North Central Nigeria

Authors: Celestine.O.Ani, Matthew. J.Olasunkanmi, Paschal.U.Chime, Pamela.S.Anyaeji, Chinemerem.C.Nworgu, Uzoigwe .J.Uzowulu, Pamela.O.Okorie, Sandra.U.Ugwu

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.230

Abstract

A total of 150 subjects were used for this study. Out of these numbers 50 were HIV-infected patients on Antiretroviral therapy (ART) and 50 were not on ART. The remaining 50 were screened HIV negative individuals drawn from the donation unit to serve as control. The subjects were made up of both sexes, ages ranging from 16 – 54 years. Blood samples were collected and analyzed for electrolytes such as Na+, K+, Cl, HCO3-, and serum urea and creatinine. Biochemical parameters were analyzed for mean±Standard Deviation, and student’s t-test for paired observation. All biochemical data were expressed as mean ± SD with the level of significance set at P < 0.05 confidence interval. There was a significant difference P < 0.05 in plasma creatinine and urea levels in patients with infected and treated (IAT) and infected and not treated (INT) when compared with controlled subjects. The  plasma creatinine level was also higher in INT than those of IAT with an insignificant difference. There was no significant difference in serum, Na+, K+, Cl-, HCO3- of IAT and INT when compared with control. Therefore this work recommends a periodic renal evaluation of HIV-infected patients to see the effect of the virus and probably drug on the serum electrolytes as this would help in the change of line of drug if effect or impairment is noticed early.

Keywords; HIV infected and treated, HIV infected untreated, serum electrolytes, Patients.

References

  1. Rao T, Filippone E., Nicastri A, et al: Associated Focal segmented glomeruloscl-erosis in the acquired immunodeficiency syndrome N. Engl J. Med. 310: pp.66-673. 1984
  2. Lucas G.M., Eustace J.A., Sozio S.,Mentari E.K. et al. Highly Active Antiretroviral Therapy and the Incidence of HIV-1-associated Nephropathy: a 12-year cohort study. 18: pp.541-546. 2004
  3. Anthony E.Z., Thomas P., John B., Anne M. Robert H. and Gregory B. Tenofovir Associated Acute and Chronic Kidney Disease: a case of Multiple drug Interac-tions. Clin.Inf. Dis; 24: pp.283-290. 2006
  4. Chioma P.E., Fatiu A; Abubakr S; Kayoke A; Friday W. and Adewale A; Renal Dieseas in HIV-seropositve patients in Nigeria: An assessment of Prevalence, Clinical Features and Risk Factors. Nephrology Dialysis Transplantation, doi:10.1093/ndt/gfm836. 2007
  5. Wyatt, C.M. and Klotman, P. HIV-1 and HIV-Associated Nephropathy 25 years later. Viruses and Disease of the Kidney. Department of Medicine, Division of Nephrology, mount Sinai, School of Medicine, New York. 2(1): S20. 2007
  6. Guyton, A.C. and Hall, E.J.: Textbook of Medical Physiology. Saunders. An Imprint of Elsevier New Delhi. India. 11: pp.307-415. 2006.
  7. Cockcroft DW, Gault M.H. Prediction of creatinine clearance       fromserum creatin-ine. Nephrology Journal. 1976; Vol 16: pp. 31-41.
  8. Van Slyke, D.D. Journal of Biology and Chemistry. Vol 58. Pp; 523. 1923-24; 73,121 1927.
  9. Schales and Selma S.A simple and accurate method for the determination of  chloride in Biological fluids, Journal of Biology and Chemistry, 1941 vol 140; pp.879-884
  10. Natelson S, (1950). The routine use of Perkin-Elmer flame photometer in the clinical laboratory. Am. J. of Clin. Pathol. Vol; 20: pp. 463-472
  11. Murphy G.M, Barbara H, Billing D and Baron N. A fluorimetric and enzymatic method of estimastion of serum total bile acids.Journal of clinical Pathology. Vol 23; pp.594-598. 2003.
  12. Follin R, Wu H, System of blood analysis. J. Biol and Chem. vol :32. 81-86 HIV and Direct Damage of organs.: AID. 17 Supplement 1: 551-             Lippincott Williams and Wilkins, Inc. 1919
  13. Jaffe M,. Uber den mederschlag,welchen Dikrinsaura in normal erzengt und uber eine neue reaction dei kreatinin. Z. physio. Chem.. vol 10; pp. 391-40. 1886
  14. Rakel R,E.Conns current therapy W.B Saunders CO. United State of America Pp.43-53. 1998.
  15. Hitner H. and Nagle B.. Pharmacology An introduction Graw-Hill, 5thEd. pp. 523-33. 2005.
  16. Afhami S.,Rasoulinejad M.,Razeghi , Shahriari S., Esmailpour N.,Renal Disorders in HIV-Infected  patients. Arch.  Iran Med. 10(3): pp 335-338.            2007

17. Carlos C. ,Elena B. Elisa R., Adela    R et al. Hyperkalemia in patients infected with human immunodeficiency virus; Involve-ment of a systemic       mechanism. Kidney International       56, pp.198-2005.

Corresponding Author

Celestine.O.Ani

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