Title: A Study on Clinico-Radiological Profile of Children Presenting with Seizure in a Tertiary Care Hospital in Nepal: A Cross-Sectional Study

Authors: Dr Sadhan Mukhi, Dr BS Salooja

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.229

Abstract

Objective: To study the clinico-radiological profile of children presenting with seizure in a tertiary care hospital in Nepal.

Methods: This was a prospective cross-sectional study. Children presenting with seizures were included in the study. The children of either sex and aged 0-16 years were included in the study. Neuroimaging of all the children was done by computed tomography (CT) of head.  Number of lesions were counted in CT scan of head and labeled as single or multiple. The findings were reported in the form GTCS, partial seizure and others.

Results: Out of the total 168 children with seizures, 138 (82.1%) had GTCS and 30 (17.3%) had partial seizures. GTCS was slightly higher among male children (82.7%) compared to females (81.2%). However, partial seizure was slightly lower among male children (17.3%) compared to females (18.8%). The percentage of GTCS and partial seizures was 80% and 20% in vesicular stage respectively. The percentage of GTCS and partial seizures was 89.5% and 10.5% in who fever was present. On CT scan, the percentage of GTCS and partial seizure was 86.3% and 13.7% respectively in whom NCC was found.

Conclusion: The study showed that seizure is one of the major causes of hospital admissions in children, particularly in the children. Febrile seizure is the most common cause of seizure in children and majority of them have generalized form of seizure. Seizure control with single drug, seizure without recurrence and idiopathic seizure are favorable prognostic factors.

Keywords: Seizure, Clinical, Generalized tonic-clonic seizure, Partial seizure.

References

  1. Ravindernath, Singh V. Role of MRI in evaluation of seizures. IAIM, 2016; 3(12): 127-136.
  2. Goodridge DMG, Shorvon SD. Epileptic seizures in a population of 6000 demography, diagnosis and classification and role of the hospital services. Br Med J, 1983; 287: 641-647.
  3. Bhalla A, Das B, Som, Prabhakar S, and Parampreet Kharbanda S. Status epilepticus: Our experience in a tertiary care centre in Northwestern India. J Emerg Trauma Shock. 2014; 7(1): 9-13.
  4. Nair PP, Kalita J, Misra UK. Status epilepticus: Why, what, and how. J Postgrad Med. 2011;57:242–52.
  5. Cherian A, Thomas SV. Status epilepticus. Ann Indian Acad Neurol. 2009;12:140–53.
  6. Kalita J, Nair PP, Misra UK. A clinical, radiological and outcome study of status epilepticus from India. J Neurol. 2010;257:224–9.
  7. Yun C, Xuefeng W. Association between seizures and diabetes mellitus: A comprehensive review of literature. Curr Diabetes Rev. 2013;9:350–4.
  8. Tiamkao S, Suko P, Mayurasakorn N. Srinagarind Epilepsy Research Group. Outcome of status epilepticus in Srinagarind Hospital. J Med Assoc Thai. 2010;93:420–3.
  9. Adhikari S, Sathian B, Koirala DP, Rao KS. Profile of children admitted with seizures in a tertiary care hospital of Western Nepal.BMCPediatr. 2013; 13:43.
  10. Chen CY, Chang YJ, Wu HP: New-onset Seizures in Pediatric Emergency. PediatrNeonatol 2010, 51(2): 103–111.
  11. Huang CC, Chang YC, Wang ST: Acute Symptomatic Seizure Disorders in Young Children-A Population Study in Southern Taiwan. Epilepsia 1998, 39(9): 960-64.
  12. Keranen T, Sillanpaa, Riekkinen P. Distribution of seizure types in an epileptic population. Epilepsia. 1988; 29(1): 1-7.
  13. Idro R, Gwer S, Kahindi M, Gatakaa H, Tony Kazungu T, Ndiritu M. The incidence, etiology and outcome of acute seizures in children admitted to rural Kenyan district hospital. BMC Pediatrics. 2008, 8:5.
  14. Goldstein JL: Evaluating new onset of seizures in children. Pediatr Ann 2004, 33(6):368–74

Corresponding Author

Dr Sadhan Mukhi

Professor & Head, Department of Radiodiagnosis, Universal College of Medical Sciences and TH,

Bhairahawa, Nepal

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