Title: Acute Transverse Myelitis Associated With Dengue Viral Infection

Authors: Dr Ramesh Chandra, Dr Sandeep Kumar, Dr Sunil Mahavar, Dr Swati Srivastava, Dr Raman Sharma

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.180

Abstract

Background: Acute transverse myelitis is a very rare complication of dengue viral infection. Very few cases have been previously reported.

Case Presentation: A 38-year-old man developed acute transverse myelitis 8 days after the onset of a dengue viral infection. Magnetic resonance imaging of spinal cord showed hyper intensity on T2W at T7-T8. Laboratories studies revealed a positive Dengue serology. Treatment with intravenous methyl prednisolone and physiotherapy yielded a partial recovery, followed by complete resolution at 6 month.

Conclusion: Acute transverse myelitis is a rare manifestation of dengue infection that can occur in either the peri-infectious or postinfectious phases.

References

1.      Solomon T, Dung NM, Vaughn DW, Kneen R, et al Neurological manifestations of dengue infection. Lancet. 2000;355:1053–1059.

2.      Patey O, Ollivaud L, Breuil J, Lafaix C. Unusual neurologic manifestations occur-ring during dengue fever infection. Am J Trop Med Hyg. 1993; 48(6):793–802.

3.      Gaultier C, Angibaud G, Laille M, Lacassin F. Probable Miller-Fisher syndrome during dengue fever type 2. Rev Neurol (Paris). 2000;156(2):169–171.

4.      Jackson ST, Mullings A, Bennetts F, Khan C, Gordon-Strachan G, Rhoden T. Dengue infection in patients presenting with neurological manifestations in a dengue endemic population. West Indian Med J. 2008;57(4):373–376.

5.      Renganathan A, Keong W, Tin Tan C. Transverse myelitis in association with Dengue infection. Neurol J Southeast Asia. 1996:1(1):61–63.

6.      Leao RN, OiKawa T, Rosa ES, et al. Isolation of dengue 2 virus from a patient with central nervous system involvement (transverse myelitis). Rev Soc Bras Med Trop. 2002; 35(4):401–404.

7.      Kunishige M, Mitsui T, Tan BH, et al. Preferential gray mater involvement in dengue myelitis. Neurology. 2004; 63(10):1980–1981.

8.      Seet RCS, Lim ECH, Wilder-Smith EPV. Acute transverse myelitis following dengue virus infection. J Clin Virol. 2006; 35(3):310–312.Lum LC, Lam SK. Dengue encephalitis: a true entity? Am J Trop Med Hyg. 1996;54(3):256–259.

Corresponding Author

Dr Ramesh Chandra

Resident