Title: One Year Prospective Study on Uterine Cervix: CIN-III Associated with Microinvasive Squamous Cell Carcinoma of Cervix

Authors: Dr M. Bhavani, Dr Mohammed Ghousuddin, Dr Uma Mikkilineni

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.166

Abstract

Background: Microinvasive squamous cell carcinoma of the uterine cervix is purely diagnosed by microscopic findings only. It has been poorly defined in the past and till today it is a focus of persistent controversy.

Aims and Objective: To determine the histomorphological features in Cervical Intraepithelial Neoplasia grade III (CIN-III) coexistence with Microinvasive squamous cell carcinoma of uterine cervix.

Materials and Methods: This is a prospective study. Post operatively all the hysterectomy specimens were included in this study. These specimens were sent to histopathology lab for microscopic study. CIN-III diagnosed cases were taken in the present study to find out the coexistent microinvasive squamous cell carcinoma of uterine cervix.

Results: Total cases for study were 270 hysterectomy specimens, out of which 63 were diagnosed as CIN-III and out of which seven cases were associated with microinvasive squamous cell carcinoma of uterine cervix.

Conclusion: To conclude all the hysterectomy cases should be histopathological examined properly to exclude the association of microinvasive squamous cell carcinoma of uterine cervix with CIN-III.

Keywords: Hysterectomy specimens, Microinvasive squamous cell carcinoma of uterine cervix, CIN-III.

References

1.      Kirkland JA, Stanley MA, Cellier K. Comparative study of histologic and chromosomal    abnormalities in cervical neoplasia. Cancer 1967; 20: 1934-52.

2.      Kirkland JA. The study of chromosomes in cervical neoplasia. Obstet Gynaecol Surveys 1969;  24:784-94.

3.      Richart RM. Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynaecol 1967; 10: 748-84.

4.      Buckley CH, Butler EB, Fox H. Cervical intraepithelial neoplasia. Y Clin Pathoi 1982; 35:1- 13.

5.      Fernando mota, Microinvasive squamous carcinoma of the cervix: treatment modalities. Acta  Obstet Gynecol Scand 2003; 82: 505–09.

6.      Tsukamoto N, Kaku T, Matsukuma K, et al. The problem of stage la (FIGO 1985) Carcinoma of the uterine cervix. Gynaecol Oncol 1989; 34:1-6.

7.      Javaheri G. Microinvasive carcinoma of the uterine cervix. Int J Gynaecol Obstet 1978; 16:106-14.

8.      Anderson MC, Hartley RB. Cervical crypt involvement by intraepithelial neoplasia. Obstet Gynaecol 1980; 55:546-50.

9.      Abdul-Karim FW, Fu YS, Reagan JW, Wentz WB. Morphometric study of intraepithelialneoplasia of the uterine cervix. Obstet Gynaecol 1982; 60:210-4.

10.  Demopoulos RI, Horowitz LF, Vamvakas EC. Endocervical gland involvement by cervical intraepithelial neoplasia grade III. Cancer 1991; 68:1932-6.

11.  Ng ABP, Reagan JW. Microinvasive carcinoma of the uterine cervix. Am J Clin Pathol 1969; 52: 511-29.

12.  Sedlis A, Sol S, Tsukada Y, et al. Microinvasive carcinoma of the uterine cervix: a clinical-pathologic study. Am J Obstet Gynecol 1979;133 : 64-74. 

Corresponding Author

Dr M. Bhavani

H.no: c-108, Phase-2, Hill colony, Vanasthalipuram, Hyderabad-500070

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