Title: Primary Germ Cell Tumour of Testis with Sarcomatous Changes: A Unique Case Report
Authors: Ashutosh Silodia, Muktesh Khandare, Piyush Kumar Panchariya, Dhananjay Sharma
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.154
Abstract
This paper reports a unique case of undifferentiated germ cell tumour with sarcomatous changes. The lack of differentiation into any specific germ cell type along with microscopic spindle and plump cells with immunohistochemistry positive for desmin and high ki67index but negative for PLAP along with normal markers of testicular malignancy apart from increased LDH marks the presence of undifferentiated germ cell tumour with sarcomatous changes and a high proliferative index. Although the patient had the localised disease at the time of presentation, the prognosis of the disease expected to be guarded and needs atailored and individualised approach for a better management and control of disease.
Keywords-Germ Cell Tumour, Sarcoma, Undifferentiated testicular tumours, Testis, Rhabdomyoblastoma, Testicular Tumour Markers.
References
1. Malagon HD, Valdez AM, Moran CA, et al. Germ cell tumours with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol 2007;31:1356-62.
2. Luke T. Lavallée, Nicolas LD Roustan Delatour etal. A unique case of a sarcoma arising in a testicular non-seminomatous mixed germ cell tumour with a predominant yolk sac component . Can Urol Assoc J 2011;5(1):E81-E83; DOI:10.5489/cuaj.10069
3. Ulbright TM, Michael H, Loehrer PJ et al. Spindle cell tumours resected from male patients with germ cell tumours. A clinicopathologic study of 14 cases. Cancer 1990;65:148-56.
4. Brian Kelly, Dara Lundon etal Embryonal rhabdomyosarcoma of the testis. Can Urol Assoc J 2011;5(1):e7-e10; DOI:10.5489/cuaj.10047
5. Ambrose J. Hertzog Rhabdomyosarcoma Of The Testis Report OF Two CASES. amjcancer/28/1/131
6. A Korfel, L Fischer etal Testicular germ cell tumor with rhabdomyosarcoma successfully treated by disease-adapted chemotherapy including high-dose chemotherapy: case report and review of the literature. bmt/journal/v28/n8/full/1703212
7. Armita Bahrami, Jae Y. Ro, and Alberto G. Ayala (2007) An Overview of Testicular Germ Cell Tumors. Archives of Pathology & Laboratory Medicine: August 2007, Vol. 131, No. 8, pp. 1267-1280.
8. Jaclyn C Milose Christopher P Filson etal Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance. oaju-4-001
9. Kabukcuoglu F, Sungun A, Senturk BA, et al. Mixed germ cell tumour of the ovary with sarcomatous component. Pathol Oncol Res 2001;7:60-2.