Title: Evaluation of tumor necrosis factor-α (TNF-α) and C-reactive protein over lipase amylase ratio for acute pancreatitis in north Indian population
Authors: Sweta Kumari, Amod Kumar, Musarrat Parveen, Amitesh Kumar, S.S.Haque, Md.Tanweeruddin
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.68
Abstract
Acute pancreatitis is an acute inflammatory disease of pancreas. Pancreatitis is due to premature, intra-pancreatic activation of pancreatic proenzymes. Increased levels of serum amylase and lipase establish the diagnosis of acute pancreatitis. Aim of the study was to determine the ratio of serum lipase to serum amylase (L/A) along with TNF-α and CRP in acute pancreatitis patients in north Indian population. The mean lipase/ amylase ratio (4.17±1.27 U/L) levels are significantly higher in severe acute pancreatitis. The study showed no significant age difference between group A (N=60; mean age 40.25±12.31 years) and control group B (N=60; mean age 37.92±9.69 years). Out of 60 patients of acute pancreatitis, 32 were having severe disease with CRP level between 96-192 mg/l while in mild disease 18 patients were having severe disease with CRP level between 24-48 mg/L and only10 patient were having normal CRP level i.e. below 8 mg/L, and TNF-α in case of acute pancreatitis 12.20±3.32 compared to control(9.86±4.57) pg/ml The lipase/ amylase ratio is a good predictor factor and is useful in distinguishing acute episode of alcoholic from non-alcoholic acute pancreatitis. It may useful in predicting the severity of acute pancreatitis.
Keywords: Acute pancreatitis; lipase; amylase; lipase/ amylase ratio (L/A).
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