Title: Some Oxidative Stress Markers in Pregnant Anemic Woman
Authors: P. A. Waghmare, K. N. Pujari, S. C. Choudhari
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.213
Abstract
Anemia is common disease during pregnancy which is known to promote oxidative stress due to insufficient tissue oxygen supply leading to increased free radical generation and very low level of circulating red blood cells and mobile free radical scavengers which protect the tissues from reactive oxygen species (ROS) mediated damage. In aerobic organisms, free radicals or reactive Oxygen Species (ROS) are produced by normal cellular metabolism or by endogenous sources. These species can cause damage to all bio-molecules such as poly-unsaturated fatty acids, DNA and proteins. Malondialdehyde (MDA) is a product of lipid peroxidation of polyunsaturated fatty acids. We have determined the serum MDA, serum uric acid and erythrocyte SOD in pregnant anemic women and pregnant healthy woman (control). We found significantly increased MDA and uric acid significantly decreased erythrocyte SOD in pregnant anemic women as compared to control. This may indicate increased oxidative stress in pregnant anemic woman.
Keywords: Anemia, Uric acid, Superoxide Dismutase
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