Title: Clinical and Angiographic Profile of Suspected Coronary Artery Disease Patients in Central India
Authors: Prof. Dr. B. S. Yadav (DM), Dr Saket S. Khetan, Prof. Dr T. N. Dubey (DM)
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.144
Abstract
Introduction: Coronary artery disease (CAD) is a leading cause of mortality worldwide and by the year 2020, will be first in the leading causes of disability. While the death rates have been declining for the past 3 decades in the west, these rates are rising in India.
Material and Methods: This observational study consisting of 200 subjects aimed to clarify the clinical and angiographic profile of suspected CAD patients. Following factors were analysed: age, sex, menopausal status, hypertension, diabetes mellitus, dyslipidemia, tobacco chewing, smoking, CRP, obesity, serum uric acid, family history of premature CAD, thyroid profile, USG abdomen for fatty liver and gallstones, ECG and CAG.
Results: The study consisted of 71% males and 29% females. Dyslipidemia (77%) was the most common risk factor followed by obesity (62%) and HTN (50%) while 32.5% were diabetics. Elevated serum uric acid (39.5%), fatty liver (20%) and gall stones (3%); subclinical (17.5%) and overt hypothyroidism (7%) were also highly prevalent. Significant correlation between independent risk factors with severity of CAD is found with Age, Diabetes mellitus, Thyroid abnormality and serum uric acid. The correlation failed to reach statistical significance between other variables.
Conclusion: This study confirms that along with traditional risk factors like Age, male gender,menopause, diabetes, HTN, obesity, smoking the new factors like hypothyroidism, serum uric acid, CRP, fatty liver and gallstones also play a significant role in the pathogenesis of severe CAD which if modified and treated timely can prevent the ruthless assault of severe CAD in young Indians.
Keywords: Angiography, CAD, CAG, CRP, Risk Factors, ECHO, ECG.
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