Title: Ratio of Atherogenic and Antiatherogenic Lipoproteins in RVO
Authors: Dr Samreen Rafique Shaikh, Dr Pooja Nitin Joshi, Dr Arif Ansar Shaikh
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.94
Abstract
Retinal vein occlusion is the most common retinal vascular disease after diabetic retinopathy. Due to its multifactorial nature, diagnosis and management remains a challenge. Hyperlipidemia is one of the risk factors. So a case control study was undertaken to determine levels of serum lipids and ratios of atherogenic to antiatherogenic lipoproteins. Total 60 patients of the study were divided into group A (30 patients of fundoscopically diagnosed RVO) and Group B (30 age and sex matched controls). The levels of Total Cholesterol, Triglyceride, Low Density Lipoprotein, Very Low Density Lipoprotein, High Density Lipoprotein and ratios of atherogenic (TG,LDL) to antiatherogenic (HDL) lipoproteins were measured. The results obtained in these patients were compared to those of controls. Data analysis was performed using Graph Pad Instat software, Version 3.05. A highly significant increase in serum levels of TG, VLDL-C (p<0.001), and a significant increase in the serum levels TC and LDL-C (p<0.05) was found in group A as compared to that of group B. However no significant decrease was found in the serum levels of HDL-C (p>0.05) in group A as compared to that of group B. There was highly significant increase in TG/HDL ratio (p<0.001) and significant increase in LDL/HDL ratio (p<0.05). The study concluded that elevated ratios of TG/HDL and LDL/HDL may contribute to the pathogenesis and progression of RVO and lowering the levels of these parameters may prevent the further complications of RVO.
Keywords: RVO, atherosclerosis, Triglycerides, Low density lipoprotein, High density lipoprotein, small density lipoproteins.
References
1. Clarkson J G: Central retinal vein occlusion. In: Ryan S3, ed. Retina.Vol.2: Medical Retina St. Louis: CV Mosby, 1989; chap 74;p.421-426
2. Hayreh SS, Zimmerman B, McCarthy MJ, Podhajsky P. Systemic diseases associated with various types of retinal vein occl-usion. Am J Ophthalmol 2001;131(1): 61–77.
3. Zegarra H, Gutaman F A, Conforto J, The natural course of central retinal vein occlu-sion. Ophthalmology.1979; 86(11):1931-42
4. Sekimoto M, Hayasaka S, Setogawa T. Type of Arteriovenous crossing at the site of BRVO. Jpn J Ophthalmol, 1992;36(2): 192-6.
5. Yau JW, Lee P, Wong TY, Best J, Jenkins A. Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management. Intern Med J 2008; 38(12): 904–10.
6. Jefferies P, Clemett R, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Aust N Z J Ophthalmol 1993; 21(4): 213–7.
7. Gunther J, Ingrid U. Scott, and Michael Ip. Retinal Venous Occlusive Disease.In: Albert DM, Miller JW, Azar DT, Blodi BA editors. Albert: Albert & Jacobiec’s Principles and Practice of Ophthalmology. 3rd edition. Philadelphia. Saunders Elsevier ; 2008;p.1755- 1773.
8. Zhao J, Sastry SM, Sperduto RD, Chew EY, Remaley NA. Arteriovenous crossing patterns in branch retinal vein occlusion. Ophthalmology 1993; 100(3): 423–8.
9. DodsonP M, GaltonD J,HamiltonA M and BlachR K.Retinal vein occlusion and the prevalence of lipoprotein abnormalities. British Journal of Ophthalmology, 1982; 66: 161-164.
10. Tarbutton PN, Gunter LR. Clin Chem. 1974; 20:724.
11. Buccolo G, David M.Clin.Chem. 1973;19:476.
12. Rifai N, Warnick GR. Lipids, lipoproteins, apolipoproteins, and other cardiovascular risk factors. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 4th ed. New Delhi: Saunders Elsevier; 2006. p. 903-81.
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultrace-ntrifuge. ClinChem 1972;18: 499-502.
14. Wong TY, Larsen EK, Klein R, Mitchell P, Couper DJ, Klein BE et al. Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the Atherosclerosis Risk in Communities & Cardiovascular Health studies. Ophthalmology 2005; 112(4): 540–547.
15. Marcucci R, Bertini L, Giusti B, Brunelli T, Fedi S, Cellai AP et al. Thrombophilic risk factors in patients with central retinal vein occlusion. Thromb Haemost. 2001;86(3):772- 776.
16. Weger M, Renner W, Steinbrugger I, Cichocki L, Temmel W, Stanger O, et al. Role of thrombophilic gene polymorph-hisms in branch retinal vein occlusion. Ophthalmology. 2005;112(11):1910-1915.
17. Dodson P M, Kubicki A J, Taylor K G, AND Kritzinger E E. Medical conditions underlying recurrence of retinal vein occlusion. British Journal of Ophthalmology, 1985; 69(7): 493-496.
18. Weiser M, Serog P, Apfelbaum M, Rousselie F. Incidence of lipid changes in rhegmatogenous retinal detachment, retinal vein occlusion and primary chronic glaucoma. J Fr Ophthalmol.1985;8(10): 619-22.
19. Maruyama, C., Imamura, K., and Teramoto, T. Assessment of LDL Particle Size by Triglyceride/HDL Cholesterol Ratio in Non-diabetic Healthy Subjects without Prominent Hyperlipidemia. J Atheroscler Thromb. 2003; 10: 186–191
20. Ip S, Lichtenstein AH, Chung M, Lau J, Balk EM. Systematic review: association of low- density lipoprotein subfractions with cardiovascular outcomes. Ann Intern Med. 2009;150:474–84.
Dr Samreen Rafique Shaikh
Address:706 Guruwar Peth Master Residency Society. Pune 411042
Contact number: 8793612004/9511815799, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.