Title: Study of clinical profile of Guillain Barre Syndrome

Authors: Priti Dave, A.G. Diwan, Baldeep Singh, Saurabh Thavare, Kunal Bonde, Bhargav Desai

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i5.192

Abstract

Guillain Barre Syndrome (GBS) is an acute fulminant, inflammatory polyradiculoneuropathy.  We studied clinical features, antecedent events, diagnostic features , incidence of respiratory paralysis and corelation of treatment modality and outcome in 30 patients of GBS admitted in a tertiary hospital.  We found tht 50% of patients had evidence of preceedings illness. The common clinical features observed where paraparesis (63.33%) and quadriparesis (36.67%) of patients. Incidence of respiratory paralysis was observed to be 13.33%. There was a direct corelation between presence of bulbar palsy and respiratory failure in our study. We also found no difference in treatment modality and outcome of patient disease between plasmapharesis and intravenous immunoglobulin.

Keywords: Guillain Barre Syndrome, Polyradiculoneuropathy, Respiratory Paralysis.

References

1.      Dhadke S V, Dhadke N, Bangar S , Korad MB.Clinical Profile of Guillain Barre Syndrome. Journal Of The Association of Physcians Of India.   March 2013; 61:168-172.

2.      Sodalagunta S R, Sodalagunta M B, Sepehrar M, Khorram H, Raja S. Guillain-Barré Syndrome: Clinical Profile  And Management.  GER MED scisep2015; 13: Doc16.

3.      Ropper A H, Brown RH. Adams and Victor`s Principles of   neurology. 9th edition New York Mc Graw hill; 2005: 1117-1127.

4.      Habib R, Saifudin M D, Islam R,Rahman A. Clinical Profile of Guillain Barre’s Syndrome Observations from a Tertiary Care Hospital of Bangladesh. Birdem Medical Journal 2017; 7:1

5.      Newswanger D L, Warren C R.Guillain-BarréSyndrome.AmFam Physician 2004 May 15; 69(10):2405-2410.

6.      Sharma G,SoodS,Sharma S. Seasonal, Age & Gender Variation of Guillain Barre Syndrome in a Tertiary Referral Center in India. Neuroscience & Medicine2013; 4: 23-28.

7.      Udaya Seneviratne U. Guillain-Barré syndrome .Post graduate medical journal December 2000; 76: 902

8.      Chen T Y, Lee C T, Guillain-Barré Syndrome Following Dengue Fever.Annals of emergency medicine july 2007 vol50, Issue 1: 94–95

9.      Tanwar V S, Saini A,  Sukhija  G, Kaur P. Post dengue Guillain Barre syndrome a rare case scenario. International Journal of Advances in Medicine; 2016 Nov; 3(4):1077-1079.

10.  Verma R, Sharma P, Garg RK, Atam V, Singh MK, Mehrotra HS. Neurological complications of dengue fever: Experience from a tertiary center of north India. Ann Indian AcadNeurol 2011; 14: 272-8.

11.  Booa Y L, Aris MAM, China P W, Wan Aliaa Wan Sulaiman WAW, Basrib H et al. Guillain–Barré syndrome complicating dengue fever. Two case reports. Tzu Chi Medical Journal December 2016; 28, (4): 157–159.

12.  Brannagan TH III, Zhou Y. HIV-associated Guillain– Barre syndrome. J Neurol Sci 2003; 208: 39–42.

13.  Sundar K, Vasanthan K, Vengadakrishnan K, Satyamurthy P, Sudhakar MK. Clinical Profile of Guillain-Barre Syndrome in a Tertiary Care Center. Int J Sci Stud 2016; 4(9):27-30

14.  John J, Kannan A. Clinicalprofile of Guillain Barre Syndrome in a tertiary carecentre. Int J Res Med Sci 2014; 2: 445-7.

15.  Ted M, Burns T M .Guillain-Barre´ Syndrome Semin Neurol. 2008 April; 28(2):152-167.

16.  Paul B S,Bhatia R ,Prasad K,Padma M V.Clinical predictors of mechanical ventilation in guillain Barre syndrome.Neurology India 2012; 60 92 :150-153.

17.  Meena A. K, Khadilkar S. V, Murthy J. Treatment guidelines for Guillain–Barré Syndrome. Ann Indian Acad Neurol 2011;14,Suppl S1:73–81.  

18.  Bhargava A, Banakar B F, Pujar G S, Khichar S.A  Study of  Guillain–Barré Syndrome with reference to cranial neuropathy and its prognostic implications. Journal of neurosciences practice Nov 2014; (1): 543-547.

19.  Harms M.Inpatient Management of Guillain-Barré Syndrome. Neurohospitalist . 2011 Apr; 1(2): 78–84.

 

20.  Netto AB, Taly AB, Kulkarni GB, Uma Maheshwara Rao G S, Rao S. Prognosis of patients with Guillain-Barré syndrome requiring mechanical ventilation. Neurol India 2011; 59: 707-11

Corresponding Author

Priti Dave

Professor of Medicine, Bharati Vidyapeeth University Medical College, Pune

Email- This email address is being protected from spambots. You need JavaScript enabled to view it., Pin- 411045.Ph No-9822790490