Title: Palonosetron and Granisetron for the Prevention of Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy: A Prospective Comparative Randomised Active Controlled Trial
Authors: Jigisha Makwana, Dipal Vadodariya, Bhavin Vadodariya
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.203
Abstract
Background: Selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are reported to have potent antiemetic effects for postoperative nausea and vomiting (PONV). The purpose of this study was to prospectively evaluate the efficacy of Palonosetron and Granisetron for the prevention of PONV in patients undergoing laparoscopic cholecystectomy.
Methods: In this prospective, randomized observational study, 70 patients who were undergoing laparoscopic cholecystectomy under general anaesthesia were enrolled. Patients were divided into two groups: the palonosetron (1.5 mg/kg,i.v.; n = 35), and granisetron group ( 0.05mg/kg i.v.; n = 35). The treatments were given before the end of surgery. The incidence of PONV, severity of nausea/vomiting, and the use of rescue antiemetic requirements during the first 48 h after surgery were evaluated.
Results: The overall incidence of PONV was 26.5 % for this series. The number of complete responders at 48 hr after the surgery was 20 (57 %) for granisetron, and 23 (65%) for palanosetron representing no statistical difference (P = 0.086).
Conclusions: Palanosetron is more effective in prevention of PONV in patients undergoing laproscopic cholecystectomy surgeries as compared to granisetron especially in 24-48 hr period postoperatively.
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