Title: Comparison of the Induction and Recovery Characteristics of Propofol and Thiopentone Sodium for Gynaecological Diagnostic Day Case Laparoscopies

Authors: Dr Mohan David .M, Dr Chitra V.R

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i4.190

Abstract

Background: Over the past three decades, outpatient surgery has grown at an exponential rate. Various surgical conditions have been diagnosed and treated using laparoscopy on a day care basis.

Aim: To study the induction characteristics like average time for induction of anaesthesia, hemodynamic effects  like changes in heart rate, systolic and diastolic blood pressure, presence or absence of apnoea, involuntary movements and pain on injection,. to study recovery characteristics, incidence of postoperative nausea and vomiting.

Materials and Methods: A randomized controlled double blind study involving 60 patients aged 20 to 40 years ASA PS 1 undergoing daycare laparoscopic surgery lasting less than 45 minutes. Group A received propofol 2.5mg/kg bodyweight and group B received thiopentone sodium 5mg/kg body weight.

Result: Our study revealed propofol to be superior to Thiopentone sodium for daycare surgery as induction agent.

Keywords: Laparosccopic  surgery, Daycare anaesthesia, Propofol, Thiopentone sodium.

References

1.      Barker p,Langton J A,Murphy P, Row-botham DJ. Effect of prior administration of cold saline on pain durinf propofol injection.Anaesthesia46:1069-70;1991

2.      Berggren L,Eriksson I, Midazolam for induction of anaesthesia in outpatients :a comparison with Thiopentone .Acta Anaesthesiologica Scandinavica 25;4920-6;1981

3.      Borgeat A,Wilder Smith OH,Saiah M, Rifat K.Subhypnotic doses of propofol possess direct antiemetic properties AN Aesthesia and Analgesia 74:539-41;1992

4.      Chittleborough MC,Osborne GA,Rudkin GA,Vickers D.Double blind comparison of patient  recovery after binduction with thiopentone or propofol for day care relaxant GAAnaesthesia and Intensive acare 20;169-73;1992

5.      Cooper GM Recovery from anaesthesia, Clinics in Anaesthesiology 2 ;145-62;1984

6.      Cullen P.M,Turtle M,Prys Roberts .Effect of propofol anaesthesia on baroreflex activity in humans Anaesthesia and Analgesia 66;1115,1987

7.      De GroodP.M.R.M,Harbers JBM et al. Anaesthesia for laparoscopy. A compa-arison of five techniques incldinf propofol, etomidate, thiopentone and isoflurane anaesthesia 42;815.1987

8.      Dundee JW. Intravenous anaesthesia and need for new agents. Postgraduate Medical Journal 3-6,1985

9.      Edelist G ;Acomparison of propofol and thiopentone as induction agent in outpatient surgery Canadian Journal of Anaesthesia 34;110-6;1987

10.  Gan TJ,Ginsberg B, Grant AP et al;Adouble blind randomized comparison of ondansetron and intraoperative propofol to prevent potoperative nausea and vomiting anaesthesiology85;1036,1996

11.  Grounds RM.Twigley AJ,Carli F;the hemodynamic effects of thiopentone and propofol Anaesthesia 40.735,1985

12.  Hudson R J,Stanski DR,Burch PG; Pharmacokinetics of methohexital and thiopentone in surgical patients Anaesthesiology  59;215.1983

13.  Korttila K,Anaesthesia for day surgery. Recovery and discharge.Acta Anaesthesio-logica Scandinavica,35 108-113,1991

14.  Ogg T W.Assessment of postoperative outpatient cases British Medical Journal 4 ;573-6,1972.

15.  Stark RD,Binks SM,Dukka VN,;A review of the safety and tolerance of prpofol, Postgraduate Medical Journal 61;152,1985

Corresponding Author

Dr Mohan David .M

Assistant Professor, Anaesthesiology

Govt Medical College, Palakkad