Title: Role of Serum Magnesium in Pregnancy with Pre-Eclampsia
Authors: Dr Sophiamma Joseph, Dr Mallika Gopinath
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.188
Abstract
Background: Hypertension complicates 5-8% of pregnancies worldwide. Hypertensive disorders of pregnancy particularly eclampsia with convulsions result in 13% of all maternal death. pre- eclampsia is the occurrence of new onset of hypertension and proteneuria after 20 weeks of gestation. MMR averages 16 per lakh live births in developed countries and 440 per lakh live births in developing regions.
Objectives
1. Analysis of risk factors of pre-eclampsia patients with that of normal pregnant women.
2. To compare the serum magnesium levels of pre-eclampsia patients with normal pregnant women.
Materials and Methods: Cross sectional study was done in a tertiary care centre. 30 pre-eclampsia patients admitted in Sree Avittom Thirunal Hospital, Thiruvananthapuram and 30 pregnant women attending Outpatient Department in the same hospital were taken. Baseline characteristics of the subjects like age, period of gestation and socio economic status were assessed. Data was collected regarding clinical features of pre-eclampsia. Magnesium was estimated by Arsenazo method by collecting 5ml of venous blood.
Analysis and Results: Analysis of risk factors for pre-eclampsia between pre-eclamptic women and normal women did not have any results of statistical of significance.
Analysis of clinical features of pre-eclampsia with normal pregnant women showed BMI was higher in pre-eclamptic women. Mean systolic and diastolic pressure were elevated among pre-eclamptic women. IUGR was more in pre-eclampsia. Magnesium levels were lowered in the first trimester of pregnancy in pre-eclampsia, when compared to normal pregnant women.
Conclusion: Serum magnesium was significantly lowered in the first trimister of pregnancy in women with pre-eclampsia.
Relevance of the study: In women with pre-eclampsia magnesium may be supplemented from the first trimester by magnesium rich diet and pharmacological intervention. by magnesium supplementation as tablets to reduce the incidence of pre-eclampsia.
Keywords: pre-eclampsia, Maternal Mortality rate, Serum Magnesium, IUGR.
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