Title: Serum Adenosine Deaminase and IL 6 as Inflammatory Marker in Rheumatoid Arthritis
Authors: Ravela Malathi, Prasad Veeragandham, Anindita Banerjee, Abhishek Chattopadhyay, Upal Banerjee, Sanjay Kothari
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.147
Abstract
Background & Objectives: Rheumatoid arthritis (RA) is a prototypical inflammatory joint disease. The degree of inflammation is reflected in the extent of joint damage, which further has influence on the quality of life of patients with RA. Serum adenosine deaminase (ADA) and IL-6 have been previously proposed to predict disease activity in patients with RA. The aim of this study was to investigate the level of serum ADA and IL-6, and the relationship between ADA and IL-6 as disease activity markers, in a group of patients with RA and compared with healthy subjects.
Methods: Sixty two RA patients and forty six age and sex matched healthy controls were included in the study. ADA activity and IL-6 levels in serum were measured in all the subjects and correlated.
Results: Serum ADA level was found significantly higher among RA subjects with respect to controls (43.73 ± 19.74 versus 18.96 ± 4.83 U/L; P < 0.0001). Moreover, serum IL 6 levels were also increased in RA cases as compared to controls and were statistically significant (19.48 ± 9.81 versus 8.33 ± 4.89 U/L; P < 0.0001). However, no correlation was observed between serum ADA with serum IL 6 level (r = 0.528; P = 0.237) among RA subjects as well as in controls (r = 0.071; P = 0.615).
Conclusion: Study showed a correlation study in which serum ADA does not correlate with IL 6 levels which means that they are not inter-dependent on each other and their levels rise individually. However, further larger and well controlled studies are needed to establish its role as inflammatory marker.
Keywords: Adenosine deaminase, IL-6, rheumatoid arthritis, serum.
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