Title: The Prevalence and Clinico-Epidemiological Profile of Celiac Disease in Anaemic Children Admitted At a Tertiary Care Hospital of North West Rajasthan (India)
Authors: Dr Vikash Katewa, Dr Vijendra Kumar Garg, Dr Suman Katewa, Dr Manoj Kumar, Dr Ravi Kumar K, Dr Kapil Choradiya
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.135
Abstract
Background: Celiac disease is an immune-mediated systemic disorder elicited by gluten sensitivity in genetically susceptible people. Anaemia is a common extra intestinal manifestation of celiac disease.
Objectives: To determine the prevalence of Celiac disease in anaemic children and to explore their clinico- epidemiological profile.
Methods: A total of 1080 children having anaemia were enrolled for the study over a period of one and half years. All the enrolled children were subjected to hemogram, anti tissue transglutaminase (IgA tTg) antibody test. Children having positive serology for celiac disease underwent duodenal biopsy. The diagnosis of celiac disease was established on the basis of the revised European Society of Paediatric Gastroenterologists and Nutritionists (ESPGAN) criteria.
Results: Out of 1080 enrolled anaemic children, 130 were diagnosed as Celiac disease (12.04%). Mean age at the time of diagnosis was 6.96 ± 3.69 years. Microcytic hypochromic was the commonest type of anemia (76.93%) followed by dimorphic. Prevalence of Celiac disease was significantly higher in stunted children (22.86%) as compared to children with normal height (6.85%). Marsh stage IIIc was the commonest (61.54%) histopathological finding. The mean haemoglobin level was significantly lower in children with celiac disease when compared to those without celiac disease.
Conclusion: There is high prevalence of Celiac disease among anemic children emphasizing the need for screening of Celiac disease in anemic children.
Keywords: Celiac disease (CD), Anemia, Anti-tissue transglutaminase antibody.
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