Title: Disseminated Cryptococcosis in an Immunocompetent Adolescent

Authors: Archana Agrawal, Kanchan Thakur, Bindu Aggarwal, Prabjyot Sing

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i4.102

Abstract

Disseminated cryptococcosis usually occurs in immunocompromised patients and is often fatal. Occasionally, it affects immunocompetent persons causing respiratory and CNS involvement primarily. We present a case which was initially misdiagnosed as disseminated tuberculosis and subsequently turned out to be disseminated cryptococcosis. Relatives refused for treatment and took LAMA discharge. Even in country with high prevalence of TB in patients of PUO especially in sputum negative cases other differentials like cryptococcosis should be considered after common causes are ruled out and tissue diagnosis should be sought.

Keywords: Disseminated cryptococcosis, immunocompetent, lymph node.

References

1.      Baddley JW, Perfect JR, Oster RA, Larsen RA, Pankey GA, Henderson H, Haas DW, Kauffman CA, et al. Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease. Eur J Clin Microbiol Infect Dis 2008; 27: 937-943.

2.      Chuang YM, Ho YC, Chang HT, Yu CJ, Yang PC, Hsueh PR. Disseminated cryptococcosis in HIV-uninfected patients. Eur J Clin Microbiol Infect Dis. 2008;27:307-10.

3.      J Gupta N, Sachdev A, Gupta D and Radhakrishnan N. Disseminated Cryptococcosis in an Immunocompetent Toddler. Indian Pediatr 2017;54:145-146.

4.      F.-L. LUO1,2, Y.-H. TAO1, Y.-M. WANG1, H. LI. Clinical study of 23 pediatric patients with cryptococcosis. European Review for Medical and Pharmacological Sciences. 2015; 19: 3801-3810.

5.      Bhawna Bhutoria Jain, Debdas Bose, Rajat Mondal, Sarbani Chattopadhyay Disseminated Cryptococcosis in an Immunocompetent Child.  Turkish journal of pathology.2014.01230

6.      Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, et al. Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:291-322.

Corresponding Author

Archana Agrawal

SGRRIMH & S, Patelnagar Dehradoon, India-248001

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