Title: Comparative Study of Epidural Dexmedetomidine with Clonidine as Adjuvant to Isobaric Ropivacaine in Abdominal Hysterectomy
Authors: Muhammed Rashid O, Sunny Alex, Asif Mammutty P, C.K.Ramadas
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.40
Abstract
Background: Aim of the study was to compare epidural α2 adrenergic agonists, Dexmedetomidine and Clonidine as adjuvant to Isobaric Ropivacaine with respect to block characteristics, postoperative analgesia, sedation and hemodynamics.
Methodology: Ninety female patients of ASA physical status I and II, between 35-50 years of age scheduled for elective abdominal hysterectomy, were selected. The patients were randomly divided into three groups. Group R received 12 ml of 0.75% ropivacaine+1ml of saline, Group RD received 12 ml0.75% ropivacaine plus 1.5 μg/kg dexmedetomidine & Group RC received 12ml0.75% ropivacaine plus 2 μg/kg clonidine epidurally. Effects on hemo dynamics & respiratory parameters, sedation& block characteristics were noted.
Results: Demographic profile, duration of surgery and side effects were comparable and statistically non-significant in all the three groups. Onset of sensory analgesia at T10 and establishment of complete motor blockade was significantly earlier in the RD group. Postoperative analgesia was prolonged significantly in the RD group and consequently less epiduraltop-ups postoperatively in the first 24 hours. Sedation scores were much better in the RD group and highly significant on statistical comparison (P<0.0001).
Conclusion: Dexmedetomidine & Clonidine are effective epidural adjuvants to Ropivacaine, dexmedeto-midine being a better neuraxial adjuvant compared to clonidine for providing early onset of sensory & motor block, sedation and prolonged post-operative analgesia.
Keywords: Epidural, Ropivacaine, Clonidine, Dexmeditomidine, Abdominal Hysterectomy.
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