Title: A Rare and Aggressive, Subcutaneous Panniculitis-like T-cell Cutaneous Lymphoma

Authors: Dr Ghanshyam Verma, Dr Shikha Sharma, Dr Ajeet Negi, Dr G.R.Tegta

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i4.26

Abstract

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a distinct variant of cutaneous T-cell lymphoma, characterized by primary involvement of the subcutaneous tissue in a manner imitating panniculitis. It accounts for less than one percent of all Non Hodgkin lymphoma. A 39 year old male presented with multiple erythematous subcutaneous nodules over upper, lower limbs and trunk for 6 months, few of which gradually increased in size with central ulceration. Histopathology of lesion was suggestive of cutaneous lymphoma. Immunohistochemistry confirmed the diagnosis of subcutaneous panniculitis like T cell lymphoma

Key Words- Subcutaneous, panniculitis, T-cell lymphoma.

References

1.      Gonzalez CL, Medeiros LJ, Braziel RM, et al. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J SurgPathol. 1991; 15:17–27.

2.      Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours. Lyon France: IARC Press; 2001.

3.      Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008; 111:838–845.

4.      Slater D N. The new World Health Organization – European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. British Journal of Dermatology 2005; 153:874-80.

5.      Takeshita M, Okamura S, Oshiro Y, et al. Clinicopathologic differences between 22 cases of CD56-negative and CD56-positive subcutaneous panniculitis like lymphoma in Japan. Hum Pathol. 2004; 35:231–239.

6.      Wang CY, Su WP, Kurtin PJ. Subcutaneous panniculitic T-cell lymphoma. Int J Dermatol. 1996; 35:1–8.

7.      Bekkenk MW, Jansen JM, Meijer CJLM, Willenze R. Annual of Oncology 2004;15:1097-108.

8.      Weenig RH, Ng CS, Perniciaro P. Subcutaneous panniculitis like T-cell lymphoma: An elusive case presenting as lipomembranous panniculitis and a review of 72 cases in the literature. Am J Dermatopathol 2001; 23:206-215.

9.      Parveen Z and Thompson K: Subcutaneous panniculitis-like T-cell lymphoma: redefinition of diagnostic criteria in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Arch Pathol Lab Med 2009; 133:303–308.

10.  Go RS, and Wester SM. “Immunophenotypic and molecular features, clinical outcomes, treatments, and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma: a systematic analysis of 156 patients reported in the literature,” Cancer 2004; 101(6):1404–1413.

Corresponding Author

Dr Ghanshyam Verma

Dept. of Dermatology, Venereology and Leprosy

Indira Gandhi Medical College, Shimla, HP INDIA

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.