Title: BCR-ABL1 Fusion Gene Positive Chronic Myeloid Leukemia - Chronic Phase in Childhood
Authors: Guddi Rani Singh, Rawi Agrawal, Bipin Kumar, Ajeet Kumar, Amit Kumar Sinha, Suryajit Kumar Singh
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.10
Abstract
Philadelphia chromosome (Ph1)-positive Chronic Myelogenous Leukemia (CML) in a child below the age of 10 years is extremely rare. We have reported such a case in a 9 year old female child. Peripheral blood smear and bone marrow revealed features of CML and karyotypic study showed(Ph1) positivity. Biologic behaviour and prognosis are similar to that of adult-type of CML. we are reporting this case because of its extremely uncommon incidence.
Key Words: Chronic myeloid leukemia (CML), adult type CML, childhood leukemia.
References
1. Hara Y, Kamura Y, Oikawa A, et al. Case of pediatric chronic myeloid leukemia with bilateral visual loss onset. Nippon Ganka Gakkai Zasshi. 2010; 114:459-463.
2. Singhal M, Makharia G, Bakhshi S. Childhood chronic myeloid leukemia with celiac disease. Pediatr Blood Cancer. 2010; 54:177-179
3. Apperley J. CML in pregnancy and childhood. Best Pract Res Clin Haematol. 2009;22: 455-474
4. Wechalekar AD, Parande CM Hematological malignancies in developing countries: is CML the commonest childhood leukemia? Leukemia. 2007; 21:2194-2197.
5. Suttorp M, Claviez A, Bader P, et al. Allogeneic stem cell transplantation for pediatric and adolescent patients with CML: results from the prospective trial CML-paed I. Klin Padiatr. 2009; 221:351-357.
6. Radhakrishnan S, Das P, Singh S, et al. Presentation of childhood CML mimicking bone sarcoma. Pediatr Blood Cancer. 2009;52:901-902
7. Vardiman JW, Melo JV, Baccarani M et al. Chronic myelogenous leukemia BCR-ABL1 positive. In: Swerdlow S; Campo E, Hariis NL, et al. WHO Classification of hematopoietic and lymphoid tissue, 4th ed. Switzerland: WHO Press, 2008:32-37.
8. Sinniah D, Ariffin WA, Shiong HW, Lin HP. Chronic myeloid leukemia in Malaysian children. Singapore Medical Journal. 1981;22 (6): 350-353.
9. Mishra A, Tripathi K, Mohanty L and Pujari S. Philadelphia Chromosome positive chronic myeloid leukemia in a child: A case report. Indian Jr Hemat Blood Transfusion 2010; 26 (3): 109-110.
10. Silliman CC, Tyson RW, Wei Q, et al. Philadelphia chromosome-positive leukemia in an adolescent boy after liver transplantation J Pediatr Hematol Oncol. 2003;25: 565-568.
11. Rabinowitz I, Larson RS. Chronic myeloid leukemia. In: Greer JP, Foerster J, Lukens JN, Rodgers GM (edi). Wintrobes clinical hematology. Lippincott Williams and Williams. 11th edition. Volume 2. 2004:2235-44.
12. Millot F, Traore P, Guihot J, Welken B, Leblane T, et al. Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia. Pediatrics. 2005; 116: 140-43.