Title: Soft Tissue Lesions of Vulva: Histomorphology Vs Immunohistochemistry of These Rare Entities
Authors: Niloy Pathak, Atoshi Basu
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.215
Abstract
Soft tissue lesions of the vulvo-vaginal tract are uncommon entities and are likely to be confused clinically with more common lesions like Bartholin’s cyst or fibro epithelial polyp. Due to a common cell of origin, both histomorphology and immunohistochemistry are essential for correct diagnosis. Due to the rarity of the lesions there is limited data on the biological behaviour of these lesions. However, correct diagnosis of these benign lesions from more aggressive ones prevents unnecessary follow-ups
Keywords: Soft tissue lesion, Vulvovagina, Angiomyofibroblastoma, Angiomyoma, Angiomyxoma.
References
1. Nucci MR, Fletcher CD. Vulvovaginal soft tissue tumours: update and review. Histopathology 2000; 36; 97–108.
2. McCluggage WG. A review and update of morphologically bland vulvovaginal mesenchymal lesions. Int. J. Gynecol. Pathol. 2005; 24; 26–38.
3. Nielsen GP, Young RH. Mesenchymal tumors and tumor-like lesions of the fem-ale genital tract: a selective review with emphasis on recently described entities. Int. J. Gynecol. Pathol. 2001; 20; 105–127.
4. Fox H, Wells M. Recent advances in pathology of the vulva. Histopathology 2003; 42; 209–216.
5. McCluggage W G. Recent developments in vulvovaginal pathology. Histopathology 2009; 54, 156–173
6. Fletcher CDM, Tsang WY, Fisher C et al. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am. J. Surg. Pathol. 1992; 16; 373–382.
7. Fukunaga M, Nomura K, Matsumoto K et al. Vulval angiomyo- fibroblastoma. Clinicopathologic analysis of six cases. Am. J. Clin. Pathol. 1997; 107; 45–51.
8. Hisaoka M, Kouho H, Aoki T et al. Angiomyofibroblastoma of the vulva: a clinicopathologic study of seven cases. Pathol. Int. 1995; 45; 487–492.
9. Laskin WB, Fetsch JF, Tavassoli FA. Angiomyofibroblastoma of the female genital tract: analysis of 17 cases including a lipomatous variant. Hum. Pathol. 1997; 28; 1046–1055.
10. Tavassoli FA, Norris HJ. Smooth muscle tumors of the vulva. Obstet. Gynecol. 1979; 53; 213–217.
11. Nielsen GP, Rosenberg AE, Young RH, Dickersin GR, Clement PB, Scully RE. Angiomyofibroblastoma of the vulva and vagina. Mod Pathol 1996;9:284-91
12. Kim, HS., Park, SH. & Chi, Aggressive Angiomyxoma of Childhood: Two Unusual Cases Developed in the Scrotum. J. Pediatr. Dev. Pathol. 2003; 6: 187.
13. James White & Yuen-Fu Chan. Aggressive Angiomyxoma of the Vulva in an 11-Year-old Girl. Paed Path 1994;14:27-37
14. Dah-Ching Ding, Senzan Hsu, et al. Aggressive angiomyxoma of the vulva in a young female: A brief case report. European Journal of Obstetrics and Gynecology. 2008;140-1:128-129
15. Laskin WB, Fetsch JF, Mostofi FK. Angiomyofibroblastoma-like tumor of the male genital tract: analysis of 11 cases with comparison to female angiomyofi-broblastoma and spindle cell lipoma. Am. J. Surg. Pathol. 1998; 22; 6–16.
16. Quintero C, Sasken H, Houck KL, Hernandez EJ Angiomyofibroblastoma of the retroperitoneum: a case report Reprod Med. 2007 Aug;52(8):741-4.
17. Iwasa Y, Fletcher CDM. Distinctive prepubertal vulval fibroma. A hitherto unrecognized mesenchymal tumor of prepubertal girls: analysis of 11 cases. Am. J. Surg. Pathol. 2004; 28; 1601–1608.
18. Vargas SA, Kozakewich HP, Boyd TK et al. Childhood asymmetric labium majus enlargement mimicking a neoplasm. Am. J. Surg. Pathol. 2005; 29; 1007–1016.
19. Allen, P. W., R. B. Dymock, and L. B. MacCormac. "Superficial angiomyxomas with and without epithelial components. Report of 30 tumors in 28 patients." The American journal of surgical pathology 1988;12.7: 519-530.
20. Lee HM, Kim JM, Chu HS, Lee SH. A Case of Angiomyoma of the Inferior Turbinate. Korean J Otolaryngol-Head Neck Surg. 2002;45(12):1193-1195.
21. Hoseok I, Yeon Joo Jeong, Kyung Un Choi, and Yeong-Dae Kim. Symptomatic Posterior Mediastinal Angioleiomyoma. Yonsei Med J. 2008 Aug;49(4):666-668
22. Newman PL, Fletcher CDM. Smooth muscle tumours of the external genitalia: clinicopathological analysis of a series. Histopathology 1991; 18; 523–529.
23. Nielsen GP, Rosenberg AE, Koerner FC, Young RH, Scully RE. Smooth-muscle tumors of the vulva. A clinicopathologic study of 25 cases and review of the literature. Am. J. Surg. Pathol. 1996; 20; 779–793.
24. Morimoto, N. "Angiomyoma (vascular leiomyoma): a clinicopathologic study." Med J Kagoshima Univ 24.12 (1973): 663-683.
25. Katenkamp, D., H. Kosmehl, and L. Langbein. "Angiomyoma. A pathologo-anatomic analysis of 229 cases." Zentralb-latt für allgemeine Pathologie u. pathol-ogische Anatomie 134.4-5 (1988): 423