Title: Study on Levels of Glycosylated Haemoglobin and Urinary Microalbumin in Diabetic Cases and Healthy Controls
Authors: Alokananda Purkayastha, Mauchumi Saikia Pathak, Shafique Ahmed
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.163
Abstract
Diabetes is one of the most common endocrine disorders characterized by hyperglycaemia. Diabetic nephropathy is a consequence of long standing diabetes. The prevalence of microalbuminuria predicts progression to diabetic nephropathy. The present study was conducted to determine the prevalence of microalbuminuria in relation to HbA1c in Diabetic cases in comparison to healthy controls.
Objective of the study: Lots of studies have been conducted on the levels of microalbumin and HbA1c in a patient with diabetes mellitus. Since the role of these parameters are increasingly reviewed and evaluated, the need to carry out further such studies become obvious. The present study is thus designed to evaluate the role of microalbumin and glycated haemoglobin in predicting incipient nephropathy in diabetics so as to prevent the onset of overt nephropathy
Materials and Methods: This case-control descriptive study was carried out in a Silchar Medical College And Hospital from July2013 to july2014. One hundred known diabetic patients with age 21–90 years were included in the study. Informed consent and a structured questionnaire of each patient were recorded. Fasting venous blood and morning urine sample was collected for analysis of Fasting blood glucose, HbA1c and urinary microalbumin respectively. Statistical analysis was done using graph stat statistical software.
All p-values <0.05 were considered as statistically significant.
Results: Fasting blood glucose levels , urinary microalbumin, and blood HbA1C levels were very high in diabetic cases as compared to healthy controls ( p- value 0.0). Also the urinary microalbumin levels were very high in the diabetic cases with poor glycaemic control.
Conclusion: The present study found higher level of HbA1C and urinary microalbumin level in diabetics. Also high level of microalbuminuria in the cases which could be due to poor glycaemic control (high HbA1C >7%). Screening for microalbuminuria and HbA1c test should be done in both newly and already diagnosed diabetic patients as an early marker of renal dysfunction and glycaemic control.
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Alokananda Purkayastha
SMCH