Title: Evaluation of Biochemical Parameters in Polycystic Ovarian Syndrome
Authors: Ramzi J, Dr Fouzia. B, Mr. Prabhachandran
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.124
Abstract
Background: PCOS is the most common endocrinopathy in women of reproductive age group with increasing prevalence worldwide either due to dietary changes or lifestyle changes or a better diagnosis. It is diagnosed in a woman when it meets two of the following three criteria (i) Chronicoligo/anovulation (ii) Clinical or biochemical androgen excess with exclusion of other etiologies and (iii) Presence of polycystic ovaries in USS. This study aims to evaluate the biochemical parameter Magnesium, Fasting Blood Sugar, Uric Acid, Lipid Profile in PCOS women and to assess its effect in the these patients and to compare and correlate the assessed parameter with that of normal controls.
Methods- This study was conducted in Gynaecology OPD in SAT Hospital, Govt. Medical College. Trivandrum. Kerala-a tertiary care teaching institution. A total of 51 ultrasound diagnosed cases of PCOS women in the age group of 18-40 years age group were studied.51 women of same age group without PCOS were taken as controls. The samples were analyzed in Clinical Biochemistry Laboratory, SAT hospital and in central biochemistry lab MCH. Fully automated analyzer Olympus AU 400 P and Erba Manneim was used. Chi square test was used for comparison and P value<0.05 was considered significant.
Results: Fasting blood sugar levels were significantly increased in PCOS patients suggestive of impaired glucose tolerance.FBS showed significant positive correlation r=0.506, p = <0.001 with BMI and also for duration of illness with r = 0.499, p = <0.001
Serum magnesium levels were significantly decreased in PCOS patients suggesting increased urinary excretion of Mg in the presence of insulin. Significant negative correlation with FBS and Magnesium with r = 0.244, p=<0.001 were showed in this study.
Serum Uric acid levels were significantly increased in PCOS cases, suggestive that androgens may increase the metabolism of purines. Measurement of Uric acid may predict non classic cardio vascular risk in PCOS patients. Uric acid shows significant positive correlation with duration of illness with r=0.792, p=<0.001. Also shows a positive correlation with BMI r=0.491, pp=<0.001.
PCOS women had higher BMI, significantly increased Total cholesterol, triglycerides, LDL and VLDL values. HDL value is negatively correlated with PCOS, suggestive of the association between BMI and dyslipidaemia in PCOS cases. Results suggest the association between Mg, FBS and uric acid values.
There is a strong positive correlation between duration of illness and BMI with FBS, Uric acid, Total cholesterol, TG LDL and VLDL.
Also Mg and HDL were negatively correlated with BMI and duration of PCOS.
Conclusion: The study revealed that hypomagnesaemia and increased FBS are suggestive of increased risk of Diabetes in PCOS patients. Serum Uric acid levels are significantly increased due to pro oxidant nature and this may predict non classic cardio vascular risk in PCOS patients.
Keywords: PCOS, BMI, FBS,Uric acid, Lipid Profile., Magnesium.
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Dr Fouzia. B
Additional Prof. Dept. of O&G SAT Hospital GMC Trivandrum, Kerala
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