Title: Assessment of Thyroid Functions in Critically Ill Patients

Authors: Rohit Herekar, G.H. Tilve

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i2.121

Abstract

Background: The thyroid function tests triiodothyronine, thyroxine and thyrotropin are abnormal in critical illness.  The pattern of abnormality depends on the severity of disease and thyroidal hormones can help in prognosis of patients.

Methods: 50 Critically ill patients were enrolled in study with inclusion and exclusion criterias. The clinical, lab profile along with T3, T4 and their free levels along with TSH were measured.

Results: The thyroid functions were abnormal in 86 % of the critically ill patients. The low T3 syndrome constituted most common abnormality (44.18%). In the thyroid functions T3, free T3 , T4 and Free T4 were deranged, the values of TSH were normal . In thyroid function the low T3 T4 syndrome was associated with mortality and thyroid hormones  T3, T4, free T4 were associated with poor outcome of the patients.         

Conclusions: The thyroid functions are abnormal in critically ill patients and it is worthwhile to associate the outcome of critically ill patients depending on the abnormality of thyroid functions

References

1.      J. Larry Jameson, Anthony P. Weetman  - Disorders of the thyroid gland. 17 th edition Harrison `s  Principles of internal medicine

2.      P. Reed Larson, Terry. F. Davies, Martin- Jaen Schlumberger, and Ian. D. Hay. Thyroid Physiology and Diagnostic evalu-ation of patients with thyroid  disorders.  Williams Textbook of endocrinology.

3.      Inder J Chopra  Euthyroid Sick Syndrome: Is it a misnomer . JCE &M 1997 Vol 82 No 2.

4.      Kaptein EM: The effects of systemic illness on thyroid hormone metabolism. IN: Current Issues in Endocrinology and Metabolism: Thyroid    Hormone Metabo-lism - Regulation and Clinical Implic-ations. Ed. S-Y Wu, Boston, MA, Black-well Scientific Publications, pp. 211-237, 1991.

5.      Kaptein EM, Nelson JC: Serum thyroid hormones and thyroid-stimulating horm-one. In: Atlas of Clinical Endocrinology, Series Editor, S.G. Korenman, Vol.1, Thyroid Diseases, Volume Editor, M.I. Surks. Philadelphia, PA., Current Medicine, Inc., pp. 15-31, 1999.

6.      McIver B, Gorman CA. 1997 Euthyroid sick syndrome: an overview. Thyroid. 7:125–132.

7.      Chopra IJ.1982 Euthyroid sick syndrome: abnormalities in circulating thyroid hormones and thyroid hormone physiology in nonthyroid illness (NTI). Med Grand Rounds. 1:201–212.

8.      Michalaki M, Vagenakis AG, Makri M, et al: Dissociation of the early decline in serum T(3) concentration and serum IL-6 rise and TNF-alpha in nonthyroidal illness syndrome induced by abdominal surgery. J ClinEndocrinolMetab 2001; 86:4198-4205

9.      Wartofsky L, Burman KD.1982 Altera-tions in thyroid function in patients with systemic illness: the “euthyroid sick syndrome.” Endocr Rev. 3:164 –217.

10.  Wong TK, Hershman JM: Changes in thyroid function in nonthyroidal illness. Trends EndocrinolMetab 1992; 3:8-12

11.  Hennemann G, Docter R, Krenning EP: Causes and effects of the low T, syndrome during caloric deprivation and nonthyr-oidal illness: an overview. Acta Med Austriaca 1988;15 (suppl 1):42-45.

12.  Gardner DF, Kaplan MM, Stanley CA, et al: Effect of triiodothyronine replacement on the metabolic and pituitary responses to starvation. N Engl J Med 1979; 300:579-584

13.  Van den Berghe G, de Zegher F, Veidhuis JD, et al: Thyrotropin  and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. ClinEndocrinol 1997; 47:599-612

14.  McIver B, Gorman CA: Euthyroid sick syndrome: an overview. Thyroid 1997; 7:125-132

15.  Chow CC, Mak TW, Chan CH, et al: Euthyroid sick syndrome in pulmonary tuberculosis before and after treatment. Ann ClinBiochem 1995; 32:385-391

16.  Wehmann RE, Gregerman RI, Burns WH, et al: Suppression of thyrotropin in the low-thyroxine state of severe nonthyroidal illness. N Engl J Med 1985;312:546-552

17.  Becker RA, Vaughan GM, Ziegler MG, et al: Hypermetabolic low triiodothyronine syndrome of burn injury. Crit Care Med 1982;10:870-875

18.  Phillips RH, Valente WA, Caplan ES, et al: Circulating thyroid hormone changes in acute trauma: prognostic implications for clinical outcome. J Trauma 1984;24:116-119

19.  Morley JE, Slag MF, Elson ME. et al: The interpretation of thyroid function tests in hospitalized patients.JAMA 1983;249: 2377-2379.

20.  Wadwekar D, Kabadi UM: Thyroid hormone indices during illness in six hypothyroid subjects rendered euthyroid with levothyroxine therapy. Exp Clin Endocrinol Diabetes 112:373-7, 2004

21.  Plikat K, Langgartner J, Buettener R, J, Wrede CE Metabolism 2007 Feb 56 (2) ; 239 – 244.

Corresponding Author

Dr Rohit Herekar

Assistant Professor GMC Miraj, India

Email-This email address is being protected from spambots. You need JavaScript enabled to view it., 8605512787