Title: Study of Prevalence of Diabetes Mellitus among Patients Suffering from Thyroid Disease

Authors: Dr Chandrashekhar H R, Shekar H S, Dr Mohammad Fakruddin, Naga Deepika, Himanshu C, Roya Kadaei, C Zothanmawia

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i2.115

Abstract

Objectives: To study the prevalence of Diabetes Mellitus in patients suffering from thyroid disorders

Methodology: This study was conducted in KIMS hospital Bengaluru and it was a prospective observational study. The patients suffering from thyroid diseases and visiting outpatient department of General Medicine who satisfied the inclusion criteria were asked to get their GRBS or RBS values measured. The results were analyzed accordingly.

Results and Discussion: The study included one hundred patients who attended outpatient department. Among them, 90 patients were suffering from hypothyroidism and the rest were hyperthyroid patients. Among the 90 hypothyroid patients, 79 cases were females and 11 were males. The prevalence of diabetes mellitus among the hypothyroidism patients found to be 10% (9 patients) and where as   in hyperthyroid patients found to be 50 %. Out of 100 patients 14% of the patients (9 hypothyroid and 5 hyperthyroid) were found to have diabetes mellitus.

Conclusion: This study showed that hyperthyroid patients are more prone to have diabetes mellitus (50%) as compared to hypothyroid patients (10%).

Keywords: Diabetes Mellitus, hypothyroidism, hyperthyroidism, plasma insulin.

References

1.   1.      Wang C. The Relationship between Type 2 Diabetes Mellitus and related Thyroid Dis-eases. Journal of Diabetes Research. 2013. 10.1155/2013/390534. E pub 2013 Apr.

2.      Dennis L. Kasper, Eugene Braunwald, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson. “Harrison's Principles of Internal Medicine” 16th Edition McGraw-Hill Professional; 16 edition, July 23, 2004.Pp 2104-2804

3.      Ashrafuzzaman SM, Taib AN, Rahman R, Latif ZA. ''Prevalence of diabetes among hypothyroid subjects'' http://www.ncbi.nlm.nih.gov/pubmed/22314468.

4.      B M Singh. B Goswami and V Mallika. Department of Biochemistry, G B Pant Hospital, New Delhi, India Indian Journal of Clinical Biochemistry, 2010 / 25 (2) 141-145.

5.      Helen C Lambeth, Frankie Stents, Kashif A, LatifMD,et al,. Thyroid Dysfunction in patients with Type 1 diabetes mellitus. Diabetes Care, 2003; 26(4): 1183-1185

6.      Mireilla Hage, Mira S Zantout, Sami T. Azar - Thyroid Disorders and Diabetes Mellitus. SAGE Hindawi Access to Research Journal of  Thyroid. 2011;9(4), Article ID 439463. 1-7.

7.      Al Sayed A, Al Ali N, Bo Abbas Y, Alfadhli E Endocrine Unit, Study on complex interplay between insulin resistance and subclinical hypothyroidism. Amiri Hospital, Kuwait City, Kuwait. Endocrine Journal [2006, 53(5):653-657

8.      Maratou E1, Hadjidakis DJ, Kollias A, et, al. Studies of insulin resistance in patients with clinical and subclinical hypothyr-oidism- European Journal of Endocrinology.  2009 May;160(5):785-90.

9.      Chaoxun Wang . ‘The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases’ Journal of Diabetes Research. Apr 4, 2013. doi: 10.1155/2013/390534

10.  Thyroid Disorders and Diabetes Mellitus, Journal of Thyroid Research Volume 2011, Article ID 439463, 7 pages doi:10.4061/2011/439463

11.  Chidakel A1, Mentuccia D, Celi FS- Peripheral metabolism of thyroid hormone and glucose homeostasis. J. Thyroid. 2005 Aug; 15(8):899-903.

12.  Leonidas  H.  Duntas,  Jacques  Orgiazzi,  Georg  Brabant.  “The Interface between Thyroid and Diabetes Mellitus” Clin Endocrinology2011; 75(1):1-9.

13.  Seema Abhijeet Kaveeshwar 1 and Jon Cornwall The current state of diabetes mellitus in India, Australian Med J. 2014; 7(1): 45–48.

14.  Coiro V1, Volpi R, Marchesi C, Capretti L, et. al., Influence of residual C-peptide secretion on nocturnal serum TSH peak in well-controlled diabetic patients. Clinical Endocrinology (Oxford). 1997 Sep;47(3):305-10

15.  Emilio Ortega, Juraj Koska, Nicola Pannacciulli, Joy C Bunt and Jonathan KrakoffFree triiodothyronine plasma concentrations are positively associated with insulin secretion in euthyroid individuals. European Journal of Endocrinology (2008) 158 217–221

16.  Dimitriadis G, Mitrou P, Lambadiari V, Boutati E et, al., Epub 2006 Sep 26.Insulin action in adipose tissue and muscle in hypothyroidism. J Clinical Endocrinology Metabolism. 2006 Dec;91(12):4930-7.

17.  Shashi A, Upasana Devi and Swati Singla. CLINICAL STUDY OF INSULIN RESISTANCE IN DIABETIC PATIENTS WITH SUBCLINICAL AND CLINICAL HYPOTHYROIDISM. Department of Zoology, Punjabi University, Patiala-147002, Punjab, India International Journal of Basic and Applied Medical Sciences ISSN: 2277-2103

18.  R Satish,V Mohan. Diabetes and Thyroid Diseases-A Review. Int.J.Diab. Dev. Countries 2003; 23:120-123.

19.  Bech K, Damsbo P, Eldrup E, beta-cell function and glucose and lipid oxidation in Graves' disease. Clinical Endocrinology (Oxf). 1996 Jan;44(1):59-66.

Corresponding Author

Dr Chandrashekhar H R

Assistant Professor, Dept of General Medicine

KIMS Hospital, Bengaluru