Title: Topical Application of Human Umbilical Cord Blood in Chronic Wounds: A Clinical and Prospective Study
Authors: Vaibhav Jain, Piyush Gupta, Deepak Agrahari, Umesh Kumar, Shuchi Jain, Madhu Jain, Pradeep Jain
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.92
Abstract
Introduction
There are over 2.8 million patients with chronic wounds, treated at a cost of billions of rupees per year in India. With a chronic wound prevalence of 4.4 per 1000 of population, healing these wounds as rapidly as possible may cause a substantial reduction in morbidity.1 Inspite of many advances in wound healing research, the treatment of chronic non healing wounds still presents a challenge to the medical fraternity. Application of stem cells is found to be the future method of wound healing. Among the available sources of allogeneic cells, umbilical cord blood is quite easy to obtain, has less ethical issues, and contains multi-potent cells of low immunogenicity. Human umbilical cord blood (HUCB) remains the most abundant, readily available source of stem cells considering the global birth rate of about 133 million a year in 2011.2
References
1. Shukla VK, Ansari MA, Gupta SK. Wound healing research: A perspective from India. Int J Low Extrem Wounds 2005;4(1):7–8.
2. Huang, L., &Burd, A.An update review of stem cell applications in burns and wound care. Indian Journal of Plastic Surgery 2012; 45(2), 229–236.
3. Mulder GD, Lee DK, Faghihnia N. Autologous bone marrow-derived stem cells for chronic wounds of the lower extremity: a retrospective study. Wounds 2010;22:219–25.
4. Stanley A, Osler T. Senescence and the healing rates of venous ulcers. J VascSurg 2001; 33(6):1206–1211
5. Gurtner GC, Werner S, Barrandon Y, Lon-gaker MT. "Wound repair and regener-ation." Nature 2008; 453(7193):314-21.
6. Luo G, Cheng W, He W, et al Promotion of cutaneous wound healing by local application of mesenchymal stem cells derived from human umbilical cord blood. Wound Repair Regen2010;18(5):506-513.
7. Gluckman E, Broxmayer HE, Auerebac HD, et al. Hematopoietic reconstitution in a patient with Fanconi Anemia by means of umbilical cord from an HLA-identical sibling. N Engl J Med 1989;321:1174–8.
8. Valbonesi M, Giannini G, Migliori F, Dalla Costa R, Dejana AM. Cord blood (CB) stem cells for wound repair; Preliminary report of 2 cases. Transfus ApherSci2004; 30 (2): 153-156.
9. Jain P, Perakath B, Jesudason MR, et al. The Effect of Autologous Bone Marrow Derived Cells on Healing Chronic Lower Extremity Wounds: Results of a Randomized Controlled Study. Ostomy Wound Management 2011;57(7):38–44
10. Badiavas EV, Falanga V.Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol 2003;139:510–6.
11. Ichioka S, Kouraba S, Sekiya N, Ohura N, Nakatsuka T. Bone marrow-impregnated collagen matrix for wound healing: Experimental evaluation in a microcirculatory model of angiogenesis, and clinical experience. Br J PlastSurg 2005;58:1124–30. [PubMed: 16043157]
12. Moenadjat Y, Merlina M, Surjadi CF, Sardjono CT, Kusnadi Y, Sandra F.hUCBMNCs for deep partial thickness burn. Med J Indones 2013;22:92-9
13. Gorin DR, Cordts PR, LaMorte WW, ManzoianJO .The influence of wound geometry on the measurement of wound healing rates in clinical trials. J VascSurg 1996;23(3):524-8
14. Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, et al. Autologous bone marrow-derived cultured mesench-ymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng. 2007 Jun;13(6):1299–312.
15. Rasulov MF, Vasilchenkov AV, Onishchenko NA, Krasheninnikov ME, Kravchenko VI, Gorshenin TL et al. First experience of the use bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns. Bull Exp Biol Med 2005; 139: 141–4.