Title: A Case of Churg Strauss Syndrome
Authors: Dr Rajput S G, Dr Saoji N R, Dr Bakre A
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.103
Abstract
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) is characterized by asthma, peripheral and tissue eosinophilia, extravascular granuloma formation, and vasculitis of multiple organ systems. It is an uncommon disease with an estimated annual incidence of 1–3 per million. Autoimmunity is the postulated etiologic mechanism of the disease. The characteristic laboratory finding is a striking eosinophilia, which reaches levels >1000 cells/μL in >80% of patients. Approximately 48% of patients have circulating ANCA that is usually antimyeloperoxidase. Histologic demonstration of eosinophilic granulomas is pathognomonic. We report a case of a 42 years old male who presented with asthma, sensorimotor polyneuropathy besides constitutional features viz. weight loss & anorexia.
Keywords-Eosinophilic granulomatosis with polyangiitis, Churg-Strauss syndrome, eosinophilia, ANCA, asthma.
References
1. Langford CA, Fauci AS. The vasculitis syndromes. Ch. 385 In: Kasper DL, Hauser SL, Jameson JL, editors. Harrison's princ-iples of internal medicine, 19th ed. New York: McGraw Hill, 2016; p.2186- 2187.
2. Greco A, Rizzo MI, De Virgilio A, et al. Churg-Strauss syndrome. Autoimmun Rev. 2015;14(4):341-8
3. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritisnodosa. Am J Pathol. 1951; 27(2): 277–301.
4. Masi AT, Hunder GG, Lie JT, Michel BA, et al.The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990;33 (8):1094-100.
5. Chen KR, Ohata Y, Sakurai M, et al. Churg-Strauss syndrome: report of a case without preexisting asthma. J Dermatol. 1992;19 (1):40–47.
6. ZengM, Liu X, Liu Y. Eosinophilic granulomatosis with polyangiitis presenting with skin rashes, eosinophiliccholecystitis, and retinal vasculitis. Am J Case Rep. 2016; 17: 864–868.
7. Mouthon L, Dunogue B, Guillevin L. Diagnosis and classification of eosinophilicgranulomatosis with polyangiitis (formerly named Churg-Strauss syndrome). J Autoimmun. 2014;48-49:99-103.
8. Samson M, Puéchal X, Devilliers H, et al. Long-term outcomes of 118 patients with eosinophilicgranulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials. J Autoimmun. 2013;43(6):60–69.
Dr Rajput S G
Lata Mangeshkar Hospital, Hingna Road, Nagpur PIN- 440019
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