Title: Microalbuminuria In Nondiabetic Actute Ischaemic Stroke

Authors: Dr Anand Singh, Dr Poonam Gupta, Dr Anubha Srivastava

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i1.80

Abstract

Introduction “Cerebrovascular Disease” or “Stroke” is one of the leading causes of mortality and morbidity in adults worldwide, posing serious medical, socio-economic and rehabilitation problems. Stroke also called ‘Brain Attack’ because it involves an acute insult to the brain, is a major disabling disease. But throughout the world, unfavourable trends in stroke risk factor profile, lack of prevention programs, lack of awareness of stroke risk factors and warning signals by the public and lack of emphasis on preventive training in medical schools, portend high stroke rates and serve to widen the stroke prevention gap. This is unfortunate because stroke is well suited for prevention since it has high prevalence, high burden of illness and economic cost, well defined modifiable risk factors and effective prevention measures.

References

1.      Goldstein L. Evidence - based medicine and stroke Neuroepidemiology 1999; 18; 120-124.

2.      Hankey GJ. Stroke: how large a public health problem and how can the neurolo-gist help? Arch Neurol 1999; 56: 748 - 754.

3.      Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-126

4.      Kullo IJ, Gau GJ, Tajik AJ. Novel risk factors for atherosclerosis. Mayo Clin Pros 2000; 75: 369-380.

5.      Hatano S. Experience from a multicentre Stroke register: A Preliminary Report, Bulletin WHO 1976; 54: 541-43.

6.      Hankey GJ. Warlow CP. Transient ischemic attacks of the brain and eye. London; WB Saunders. 1994.

7.      Srinivasan AV, Balasubramnian, N. Mahesh. An Overview of Stroke - Recent perspectives, Medicine update - APICON 2002. Editor SB Gupta 878-82.

8.      Hachinski V, Norris IW. The Acute Stroke. FA Davis Company, 1985.

9.      Park. K. Parks Textbook of Preventive and Social Medicine, 14th Edition Jabalpur. Banarsidas - Bhanot Publishers; 1994.

10.  Devis HD et al. Epidemiology of Cerebrovascular Disease. In Anderson D ed. Neuroepidemiology A tribute to Bruce Schoenberg Boca Raton: CRC Press 1991; 27-53.

11.  Kameshwar Prasad. Epidemiology of Cerebrovascular Disease in India. Recent concepts in stroke. Editor B.C. Bansal : 21-27.

12.  Banford J et al. A prospective study of acute cerebravascular disease in the community: The Oxfordshire Community Stroke Project 1981-86: Methodology, demography and incident cases of first ever stroke. J Neurosurg Psych 1998; 51:1373 - 80.

13.  Rodgers A. et. al. Blood Pressure and the risk of stroke in patients with cerebrovascular disease . BMJ 1996; 313:147.

14.  Sagie A et al. The natural history of borderline isolated systolic hypertension. N Engl J Med 1993; 329: 1612-1617.

15.  Wolf PA et al. Probability of Stroke- a risk profile from the Framingham study Stroke 1991; 22:312.

16.  Shinton R et al. Meta analysis of relation between cigarette smoking and stroke. BMJ 1989; 298: 789-794.

17.  Jurgens G. et al. LP (a) serum concentration and apolipoprotein (a) phenotype correlate with severity and presence of ischemic cerebrovascular disease. Stroke.1995; 26: 1841-48

18.  Manson JE et al. A prospective study of maturity onset diabetes mellitus and risk of coronary heart diseases and stroke in women. Arch Intern Med 1991; 151:1141-1147.

19.  Jorgensen HS et al. Intracranial haemorrhage versus infarction stroke severity, risk factors and prognosis. Ann Neurol 1995; 38: 45-50.

20.  Qizilbash N. et al. Fibrinogen and lipids as risk factor of transient ischemic attacks and minor ischemic stroke. BMJ 1991; 303: 605-609.

21.  Qizilbash N et al. Von Willebrand Factor and risk of ischemic stroke. Neurology 1997; 49: 1552-1556.

22.  Welin L. et al. Analysis of risk factors for stroke in a cohort of men born in 1913 N Engl J Med 1987; 317: 521-526.

23.  Yamanouchi H et al. Embolic brain infarction in non-rheumatic atrial fibril-ation: A clinicopathologic study in the elderly. Neurology 1997; 48: 1593 - 1597.

24.  Wannamethee S et al. Patterns of alcohol intake and risk of stroke in middle aged British Men Stroke 1996; 27: 1033 - 1039.

25.  Kaplan NM. Alcohol and hypertension Lancet 1995; 345; 1588 - 1589.

26.  Shinton R et al. Body fat and stroke. J Epidemiol Community Health 1995; 49: 259 - 264.

27.  Ovencia AJ et al. Fish consumption and stroke in men. Stroke 1996; 27: 204-209.

28.  Thelle DS. Salt and blood pressure revisited. BMJ 1996; 312: 1240-1241. 

29.  Whelton PK et al. Effects of oral potassium on blood pressure. JAMA 1997; 277: 1624-1632.

30.  Lee IM et al. Exercise and risk of stroke in male physicians. Stroke 1999; 30: 1-6.

31.  Kannel WB et al. Manifestations of CHD predisposing to stroke. JAMA 1983; 250: 2942 - 2946.

32.  Craven TE et al. Evaluation of the association between carotid artery atherosclerosis and coronary artery stenosis. Circulation 1990; 82: 230-1242.

33.  Natowicz M et al. Mendelian etiologies of stroke. Ann Neurol 1987; 22: 175-192.

34.  Wade S. Smith, Claiborne Johnston, Donald Easton. Cerebrovascular Diseases, Harrisons Principles of Internal Medicine. 16th ed; Vol. II: 2372-2393.

35.  Ralph L, Sacco, Danilo Toni, Mohr JP. Classification of ischaemic stroke. Stroke Pathophysiology, Diagnosis and Management. Editor - HIM Barnett, JP Mohr, BM Stun, FM Yatsu. 3rd ed, Churchill Livingstone 1998; PP 343.

36.  Pushpa Yadav, BK Tripathi, AK Agarwal. Prognostication in stroke - Recent concepts in stroke. Editor: Bansal B. C., 301-310.

37.  Multicenter trial of hemodilution is ischemic stroke - background and study protocol. Scandinavian Stroke Study Group. Stroke 1985; 16 (5): 885-90.

38.  Loewen SC, Anderson BA. Predictors of stroke outcome using objective measure-ment scales. Stroke 1990; 21: 78-81.

39.  Bangstad HJ, Try K, Dahl JK, Hansen KF. New Semiquantitative dipstick test for Microalbuminuria. Diabetes care 1991; 14: 1094-1097.

40.  Andrew Hartland and Peter Gostling. Microalbuminuria: Yet another cardiovas-cular risk factor? Ann Clin Biochem 1999; 36: 700-703.

41.  Gosling P. Beevers DG. Urinary albumin excretion in the general population. Clin Sci 1989; 76: 39-42.

42.  Stender S. Hjelms E. In vivo transfer of cholesterol from plasma into human aortic tissue. Scand J Clin Lab Invest 1987; 47: 21-29.

43.  Lindberg G. Eklund GA. Gulberg B, Rastan G. Serum Sialic acid concentration and cardiovascular mortality. BMJ 1991; 302: 153-161.

44.  Clausen P, Jensen J, Jenson G et al. Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically health subjects. Circulation 2001; 103: 1869 - 1874.

45.  Lee P, Jerkins A, Bourkhe C et al. Prothrombotic and antithrombotic factors are elevated in patients with type 1 diabetes complicated by microalbum-inuria. Diabet Med 1993; 10 (2): 122-128.

46.  Bhattacharya A. Microalbuminuria in diabetic nephropathy and as risk factor for cardiovascular disease. Chapter 66, Medicine update. Venkatraman S 2004; 14:405-409.

47.  Kuusisto J, Mykkensen K, Pyorala K et al. Hyperinsulinemic microalbuminuria: A new risk indicator for coronary heart disease. Circular 1995; 91 (3): 831-837.

48.  American Diabetes Association, Nephro-pathy in Diabetes (Position statement) Diabetes Care 2004; 27 (1): 79-83.

49.  Rush University Hypertension Center. Microalbuminuria: What is it Why is it important? What should be done about it? J Clin Hypertens 2001; 3(2): 99-100.

50.  Parving HH et al. Early detection of patients at risk of developing diabetic nephropathy; a longitudinal study of urinary albumin excretion. Acta Endocrinal (Copenti) 1982; 100: 550-555.

51.  Viberti GC, Hill RD, Jarpet RJ et al. Microalbuminuria as a predictor of clinical nephropathy in Insulin Dependent Diabetes Mellitus. Lancet 1982; 1: 1430 - 1432.

52.  Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes. NEJM 1984; 310: 356-60.

53.  Allawi J, Jarrett RJ. Microalbuminuria and cardiovascular risk factors in Type 2 diabetes mellitus. Diabetes Med 1989; 7: 115-118.

54.  Jorge L, Gross et al. Diabetic Nephropathy: Diagnosis Prevention and Treatment. Diabetes Care 2005; 28: 176-188.

55.  Consensus development conference on the diagnosis of coronary heart disease in people with Diabetes. Diabetes care 1998; 21: 1551-68.

56.  Agarwal B et al. Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension. J. Hypertension 1996; 14(2): 223-228.

57.  Dansgaard EM et al. Microalbuminuria as predictor of increased mortality in elderly people. BMJ 1990; 300: 297-300.

58.  Gosling P, Hughes EA, Reynolds TM, Fox JP. Microalbuminuria is an early response following acute myocardial infarction. Eur Heart J 1991; 12: 508-513.

59.  Spyridon Koulouris et al. Microalbuminuria: A strong predictor of 3-year adverse prognosis in non-diabetic patients with acute myocardial infarction. Am Heart J.

60.  Roine I. Microalbuminuria: an index of severity in childhood meningitis. Pediatr Infect Dis J 1993; 12: 584-588.

61.  Shearman CP, Gosling P, Walker KJ. Is low-level protein urea a predictor of severity in acute pancreatitis? J Clin Pathol 1989; 42: 1132-1135.

62.  Pallister I, Gosling P, Alpar K, Gradley S. Prediction of post-traumatic adult respiratory distress syndrome by albumin excretion rate eight hours after admission. J Trauma 1997; 42: 1056-61.

63.  Pedersen LM et al Microalbuminuria in patients with rheumatoid arthritis. Ann Rheum Dis 1995; 54: 189-192.

64.  Mahmood N. et al. Microalbuminuria: a disease activity marker of inflammatory bowel disease. Gut 1993; 34: 524.

65.  Hickey NC et al. Effect of surgery on the systemic inflammatory response to intermittent claudication. Br J Surg 1009; 77: 1121-1126.

66.  Mykkanen L et al. Microalbuminuria and carotid artery intima-media thickness in non-diabetic and NIDDM subjects. The Insulin Resistance Atherosclerosis Study (IRAS). Stroke 1997; 28: 1710 - 1716.

67.  Else Marie Damsgaard et al. Microalbum-inuria as predictor of increased mortality in elderly people. BMJ 1990; 300: 297-300.

68.  John S. Yudkin et al. Microalbuminuria as predictor of vascular disease in non- diabetic subjects. Lancet 1988; 530-533.

69.  Heikki Miettinen et al. Proteinuria predicts stroke and other atherosclerotic vascular disease events in non-diabetic and non-insulin dependent diabetic subjects. Stroke 1996; 27: 2033 - 2039.

70.  Mlacak B. et al. Albuminuria, cardiovascular morbidity and mortality in diabetic and non-diabetic subjects in a rural general practice. Family Practice 1999; 16: 580-585.

71.  Nancy B. Beamer et al. Microalbuminuria in ischemic stroke Arch Neurol 1999; 56: 699 - 702.

72.  Yuyun MF et al. Microalbuminuria and stroke in a British population: the European Prospective Investigation into cancer in Norfolk (EPIC-Norfolk) population study. J Intern Med 2004; 255(2): 247-256.

73.  Hans L. Hillege et al. Microalbuminuria is common, also is a non-diabetic, non- hypertensive population and an independent indicator of cardiovascular risk factors and Cardiovascular morbidity, J Intern Med 2001; 249: 519-526.

74.  Wojeiech Turaj et al. The prognostic significance of microalbuminuria in non- diabetic acute stroke patients. Med Sci Monit 2001; 7(5): 989-994.

75.  Keen H, Chloverakis C. An immunoassay method for urinary albumin at low concentration. Lancet 1963; 2: 913-914.

76.  Alfredo Pegoraro et al. Simplified screening for Microalbuminuria. Ann Intern Med 1997; 127: 817-819.

77.  Magensen CE et al. Multicenter evaluation of the Micral-Test II test strip, an immunological rapid test for the detection of microalbuminuria. Diabetes cares 1997; 1642-1646.

78.  Wachtell K et al. Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy. The LIFE STUDY. Ann Intern Med 2003; 139: 901-906.

79.  UK Prospective Diabetes Study (UKPDS) Group intensive blood glucose control with Sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998; 352: 837-853.

80.  Smulders YM et al. Can reduction in hypertriglyceridemia slows progression of microalbuminuria in patients with NIDDM. Eur J Clin Invest 1997; 27 (12): 997-1002.

81.  Radrigo Tagle, Monico Acevedo, Donald G. Vidt. Micro albuminuria: Is it a valid predictor of cardiovascular risk. Cleveland Clin J Med 2003; 70 (3): 255-261.

82.  Slowik A et al. Microalbuminuria in non-diabetic patients with acute ischemic stroke: Prevalence, clinical correlates and prognostic significance. Cerebrovasc Dis 2002; 14 (1): 15-21.

83.  Beamer NB, Coull BM, Clark WM, et al, Microalbuminuria in ischaemic stroke, Arch Neurol. 1999;56:699-702.

84.  Mathur PC, Punckar P, Murlidharan R, Microalbuminuria in Nondiabetic Acute Ischemic Stroke-An Indian Perspective, Ann Ind Acad Neurol 2005,Vol.8:237-242

85.  Lima H.N., Cabral N.L., Gonçalves A.R.R., Association between Albuminuria, Glomerular Filtration Rate and Mortality or Recurrence in Stroke patients, Nephron Clin Pract 2011;117:c246–c252

86.  Yoko Watanabe, Kae Ueda, Satoshi Suda, et al, Correlation between Proteinuria and the Condition of Patients with Acute Ischemic Stroke, J Nippon Med Sch 2011; 78 (6).

87.  Gumbinger C, Sykora M, Diedler J, Ringleb P, Rocco A, Microalbuminuria: a potential prognostic marker for acute stroke,,Nervenarzt. 2012 Oct;83(10):1357-60.

88.  Mathers, CD; Boerma, T; Ma Fat, D (2009). "Global and regional causes of death." British medical bulletin 92: 7–32.

Corresponding Author

Dr Anand Singh

MLN Medical College
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