Title: Degree of Renal Dysfunction in Patients of Subclinical and Overt Hypothyroidism
Authors: Dr Sankalp Kumar Tripathi, MD, Dr M.G. Muddeshwar, MSc PhD
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.67
Abstract
Background: Thyroid hormones deficiency may lead to impaired renal function either directly or indirectly. Impaired renal function is characterized by increased serum creatinine and decreased creatinine clearance. This study was intended to evaluate the level of serum creatinine and creatinine clearance in both subclinical and overt hypothyroid patients.
Materials and Methods: 104 hypothyroid patients were divided in two equal groups namely subclinical and overt hypothyroids based on their serum TSH levels. 52 age, sex and weight matched euthyroid controls were used for comparison.
Result: Significantly raised serum creatinine was found in overt hypothyroids as compared to both subclinical hypothyroids and controls. Creatinine clearance was found significantly low in overt hypothyroids as compared to controls.
Conclusion: Decrease in creatinine clearance was found more profound as compared to increase in serum creatinine in hypothyroids. Thus creatinine clearance is better early marker for renal dysfunction in hypothyroids.
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