Title: Cardiac Sarcoidosis Causing Sudden Death
Authors: Gupta Kamal K., Behera Sameer K., Mishra Debi P.
DOI: http://dx.doi.org/10.18535/jmscr/v3i8.56
DIDS : 08.2015-XXXXXXX
Sarcoidosis is a granulomatous disease of unclear etiology. Cardiac involvement in sarcoidosis is rarely diagnosed clinically. It is not commonly fatal, but when sarcoidosis is fatal, it is most often from cardiac involvement and when sarcoidosis involves the heart, it frequently causes death. We report a case of sudden death of 48 years male, wherein sarcoidosis with cardiac involvement was diagnosed at histopathological examination. We received a heart weighed 500gms with left ventricular wall thickness 3.5cm. On microscopic examination, the heart wall shows multiple noncaseous granuloma with few multinucleated giant cells and fibrosis around it. No acid fast bacilli identified on ziehlneelsen stain. Keywords: Sarcoidosis, granulomatous, autopsy, sudden death. 1. Chapelon-Abric, Catherine, et al. "Cardiac sarcoidosis: a retrospective study of 41 cases." Medicine 83.6 (2004): 315-334 2. Suranagi, Vijayalaxmi V., Prakash R. Malur, and Hema B. Bannur. "Cardiac sarcoidosis causing sudden death." Indian Journal of Pathology and Microbiology 52.4 (2009): 566. 3. Mitchell, Richard N., Richard A. Jonas, and Frederick J. Schoen. "Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants." The Journal of Thoracic and Cardiovascular Surgery 115.1 (1998): 118-127. 4. Perry, A., and F. Vuitch. "Causes of death in patients with sarcoidosis. A morphologic study of 38 autopsies with clinicopathologic correlations." Archives of pathology & laboratory medicine 119.2 (1995): 167-172. 5. Roberts, William C., Hugh A. McAllister, and Victor J. Ferrans. "Sarcoidosis of the heart: a clinicopathologic study of 35 necropsy patients (group I) and review of 78 previously described necropsy patients (group II)." The American journal of medicine 63.1 (1977): 86-108. 6. Dubrey, Simon W., Alex Bell, and Tarun K. Mittal. "Sarcoid heart disease." Postgraduate medical journal 83.984 (2007): 618-623. 7. Cooper Jr, Leslie T., Gerald J. Berry, and Ralph Shabetai. "Idiopathic giant-cell myocarditis—natural history and treatment." New England Journal of Medicine336.26 (1997): 1860-1866. 8. Hamilton, Rebecca A., Linda Sullivan, and Barbara C. Wolf. "Sudden cardiac death due to giant cell inflammatory processes" Journal of forensic sciences52.4 (2007): 943-948. 9. Gal, Anthony A., and Michael N. Koss. "The pathology of sarcoidosis." Current opinion in pulmonary medicine 8.5 (2002): 445-451. 10. Rosen, Yale. "Pathology of sarcoidosis." Seminars in respiratory and critical care medicine. Vol. 28. No. 1. New York: Thieme Medical Publishers, c1994-, 2007.Abstract
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