Title: Gastroprotective and Antioxidant Effect of Gloriosa Superba on Indomethacin-Induced Gastric Ulcers in Rats
Authors: Siddhi Ashokkumar Mehta Falguni, Mrs. Rachana D. Sarawade, Vishakha Trivedi, Ayyub Shaikh
DOI: http://dx.doi.org/10.18535/jmscr/v3i8.27
DIDS : 08.2015-XXXXXXX
Gloriosa superba plant is well documented traditionally in Ayurvedic system of medicine and is used in treating many diseases. The present study was undertaken to evaluate the gastroprotective effect of Gloriosa superba tuber extract (GSTE) on rats at the dose of 110mg/kg body weight. Administration of test drug (110mg/kg) reduced gastric lesions as compared to Indomethacin (25 mg/kg) treated group. In vivo antioxidant levels were also evaluated. It was observed that administration of Indomethacin caused significant decrease in levels of SOD, GSH, GSHPx and increase in level of LPO. But reverse trend was seen in rats pre-treated with test drug, that is increase in levels of SOD, GSH, GSHPx and decrease in level of LPO. The results suggest that the gastroprotective activity of methanolic extract of Gloriosa superba tuber can be contributed to its constituents and antioxidant potential. Keywords: Gloriosa superba, gastroprotective, antioxidant, antioxidant enzymes. 1. Heyam Mohamed Ali Sidahmed, Ainnul Hamidah Syahadah Azizan, Syam Mohan; Gastroprotective effect of desmosdumotin C isololation from Mitrella Kentii against ethanol-induced gastric mucosal hemor-rhage in rats: Possible involvement of glutathione, heat- shock protein, sulfhydryl compounds, nitric oxide, anti-helicobacter pylori activity; BMC complementary and alternative medicine; 2013, 13:183. 2. KP.Latha, H.Kirana and HN.Girish; Anti-Implantation activity of the hydro alcoholic tuber extract of Gloriosa superba Linn in female Albino rats; IJAPBC-vol.2 (3); jul-sep, 2013. 3. Saradha devi Muthukrishnan, Annapo-oorani Subramaniyam; International journal of pharmaceutical research development (IJPRD); 2013; vol 5(06) Aug-2013(102-108). 4. CK Kokate, Practical Pharmacognosy; 4th edition; Vallabh Prakashan; New Delhi. 5. GE Trease, WC Evans; Pharmacognosy, 15th edition; WB Saunders Publishers. 6. OECD Guideline for testing of chemicals; 423 Adopted: 17th Dec 2001. 7. Fehmi Odabasoglu, Ahmet Cakir b, Halis Suleymanc, Ali Aslan d, Yasin Bayir a, Mesut Halici a, Cavit Kazaz; Gastroprotective and Antioxidant effect of Usnic acid on Indomethacin- induced gastric ulcers in rats; Journal of Ethnopharmacology 103(2006) 59-65. 8. Sati Al-dalain, Mona 1 2 S, El-Kutry and 3 Hoda S. Ibrahim; Inhibitory Effect of Aqueous extracts of Barley and Fenugreek on Ulcer induction in rats; World applied Sciences Journal 5(3): 332-339, 2008. 9. Ahmed S. AlRashidi, Suzy M.Salama, Salim S. Alkiyumi, Mahmood A Abdulla, A. Hamid A. Hadi, Siddig I.Abdelwahab, Manal M Taha, Jamal Hussiani, and Nur Asykin; Mechanism of gastroprotective effect of ethanolic leaf extract of Jasminium sambac against Hcl/Ethanol induced gastric mucosal imjury in rats; Hindawi Publishing Corporation, Volume 2012, Article ID 786426. 10. K.T. Mani, Senthnil Kumar 1, Zothan Puia1, Samir K. Samanta1, Rajiv Barik 1, Arnab Dutta 1, Bapi Gorain 1, Dilip K. Roy1, Dipan Adhikari 1, Sanmoy Karmakar1, Tuhinadri Sen; The gastroprotective role of Acanthus ilicifolius- A study to unravel the underlying mechanism of Anti-ulcer Activity; sci Pharm. 2012; 80: 701-717.Abstract
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