Title: Evaluation of Neuroprotective Activity of Bauhinia Variegata on Haloperidol Induced Catalepsy in Rats
Authors: Vishakha Rajesh Trivedi, Mrs.Rachana D. Sarawade, Siddhi Mehta, Ayyub Shaikh
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.47
An acetone soluble leaf extract from Bauhinia variegata was investigated for its neuroprotective effects in the haloperidol induced catalepsy rat model of the disease by measuring behavioural and biochemical parameters in the model. In rat model catalepsy was induced by administration of haloperidol (1 mg/kg, p.o) in wistar rats of either sex. A significant reduction in the catalepsy was observed in the drug treated groups when compared to the disease induced group. The biochemical parameters were Lipid peroxidation, Glutathione (GSH) , Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were assessed in brain. Administration of haloperidol resulted in increased lipid peroxidation and decreased levels of antioxidant enzymes i.e GSH,GSH-Px and SOD. The study showed that the plant extract significantly decreased lipid peroxidation levels and increased antioxidant enzyme levels. KEYWORDS: Bauhinia variegata, neuroprotective, antioxidant, antioxidant enzymes 1. Przedborski S, Vila M, Jackson-Lewis V. Neurodegeneration: What is it and where are we? The Journal of Clinical Investigation ,January 2003, Volume 111, Number 1. 2. Marshall R J. “The Overlooked Role of Chronic Infection in Neurodegeneration and Its Reversal Using Nutraceutical Agents”. 3. Rupavate S.(2014) Available at http://www.thehealthsite.com/diseases-conditions/world-parkinsons-day-2014-10-facts-about-parkinsons-disease/. Accessed on: 10 January 2015. 4. Navarro, A. & Boveris, A. (2009) Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease. J Bioenerg Biomembr 41: 517-521. 5. Sahu G and Gupta PK. A review on Bauhinia variegata linn. International research Journal of pharmacy 2012;3(1):48-51. 6. Sanberg PR (1980). Haloperidol-induced catalepsy is mediated by postsynaptic dopamine receptors. Nature 284: 472–473. 7. Adeyemi O Olufunmilayo et al; Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?; Progress in Neuro-Psychopharmacology & Biological Psychiatry 48 (2014) 245–251. 8. Niehaus WG, Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem. 1968;6:126–130. 9. Rotruck JTAL, Pope HE and Ganther AB Swanson Biochemical role as acomponent of glutathione peroxidase. J science., 1973; 179: 588-590. 10. Bowling AC, Schulz JB, Brown RH, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993;61:2322-5.Abstract
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