Title: Incidence and Etiological Profiling of Acute Symptomatic Seizures in Western Uttar Pradesh
Authors: Malini Kulshrestha, Gurpreet Singh, K K Dwivedi
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.41
An acute symptomatic seizure is defined as a clinical seizure occurring at the time of a systemic insult or in close temporal association with a documented brain insult (an acute medical or neurological illness). These etiologies may vary with time and place .This study was conducted with an aim to study the clinical profile of acute symptomatic seizures presenting to a tertiary care centre at North India. All patients admitted in medicine wards with recent onset seizure either alone or in association with some medical complaints were considered in the study. Detailed history, neurological examination and baseline investigations were done in all the patients. Cerebrospinal fluid (CSF) analysis was done wherever indicated and CT scan / MRI brain were carried out. EEG was done within 48 hours of seizure (if the condition of patient permitted). Total number of patients was 47 (27 male: 20 female). Majority of patients were less than 40 years (n=32) and most common presentation was single seizure (n=24, 51.1%).Status Epilepticus was seen in (n=12, 25.5%). Thirty cases had generalized tonic clonic seizures and 17 had partial seizure. CNS infections was the most common etiology (n=44.7%) neurocysticercosis being the commonest (14/47; 31%) followed by metabolic causes (n=10; 21.3%), post stroke epilepsy (7/47; 14.90%) and brain tumor (3/47; 6.3%). Three had non specific gliosis. Outcome was good in cases with single seizure. Four patients who had status epilepticus expired. Keywords: acute symptomtic seizures, etiology, incidence, outcome 1. Commission on Epidemiology and Prognosis of the ILAE-“Guidelines for epidemiological studies on epilepsy”. Epilepsia 34 (4), pp592-6, 1993. 2. Beghi, E., Carpio, A., Forsgren, L., Hesdorffer, D.C., Malmgren Sander, J.W., Tomson, T. and Hauser, W.A. “Recommendation for a definition of acute symptomatic seizure”. Epilepsia, 51 (4),pp 671-5,2010. 3. Mauri, L, Tejero-Juste, C., Escalza-Cortina, I., Jerico, I. and Morales Asin F. “Acute symptomatic epilepsies.” Review Neurology.(article in Spanish) 31 (8), 770-74,2000. 4. Beleza, P. “Acute symptomatic seizures: a clinically oriented review”. Neurologist., 18 (3), pp109-19,2012. 5. Annegers, J.F., Hauser, W.A., Lee, J.R.J. and Rocca, W ”Incidence of acute symptomatic seizures in Rochester, Minnesota1935–1984”, Epilepsia, 36,pp 327–33,1995. 6. Sander, J.W.A.S., Hart, Y.M., Johnson, A.L. and Shorvon, S.D. “National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population.” Lancet, 336, pp1267–71,1990. 7. Murthy, J.M.K and Yanga, R. “Acute symptomatic seizures —Incidence and etiological spectrum: a hospital-based study from South India.” Seizure, 8, pp162–165,1999. 8. Narayanan, J.T. and Murthy, J.M. “New-onset acute symptomatic seizure in a neurological intensive care unit.” Neurology India., 55 (2),pp 136-40,2007. 9. Rao, B.S., Vani, M.S. and Varma, G.A.R. “The study of etiological profile in new onset seizures in Indian scenario.” International Journal of Advances in Medicine, 2 (1),pp 6-12,2015. 10. Sriharsha, K. and Malali, V. “Clinical and etiological study of seizures in young adults”. Indian Journal of Basic and Applied Medical Research. 4 (2), pp76-83,2015.1 11. Sahu PS,Patros,JenaPK,SwainSK,DasBK. “Imaging and serological evidence of neurocysticercosis amongst patients with seizures in Odisha,An eastern coastal province in India.” Journal of clinical and diagnostic research.9(5),pp06-10,2015. 12. Rajshekharan V,Raghava MV,Prabhakaran V,Omen A,Muliyil J.A”ctive epilepsy as an index burden of Neurocysticercosis in vellore district ,India”.Neurology, 67(12), pp2135-9,2006.Abstract
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