Title: Treatment of Pemphigus Vulgaris in a Patient with Avascular Necrosis using Cyclophosphamide
Authors: Dr Anand Jagdish Asia, Dr Vaibhav Tapre, Dr Gajendra Raghuvanshi
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.30
Pemphigus vulgaris is an autoimmune vesiculobullous disease of the skin and mucous membrane. Large dose of steroids and prolonged treatment is required to suppress and cure the disease. This leads to various side effects one of which is Avascular Necrosis (AVN). In dermatological practice AVN has been reported more commonly with steroid use for SLE and less commonly in Pemhigus. To decrease the exposure to corticosteroids use of steroid sparing drugs have gained importance. We present a case a 54 year old male having Pemphigus vulgaris with AVN of femoral head on right side secondary to high dose corticosteroids. Patient has been treated successfully with cyclophosphamide alone. Keywords: Pemphigus, AVN, Cyclophosphamide 1. Babhulkar S. Osteonecrosis of femoral head (in young individuals). Indian J Orthop.2003 ;(37) 2 :2 . 2. Baksi D P. Avascular Necrosis. Indian J Orthop.2002; (36) . 4 :267-273. 3. Mendiratta V, Khan A, Solanki RS . Avascular Necrosis: A rare complication of steroid therapy for pemphigus .Indian J Dermatol 2008 ;(53) . 1 : 28-30 4. Mary E , Fleischli MD . Rachel H. Pulse Intravenous cyclophosphamide theraphy in Pemphigus .JAMA Network, JAMA Dermatology .1999 (135)No.1. 5. Hanumanthappa H , Rao R. Corticosteroid - Induced Avascular Necrosis of Head of femur in patient with Pemphigus Vulgaris. Indian J Dermatol Vener. 200(66) 3:147-8. 6. Barnatsks S, Goldman RM . Malignancies and Cyclophosphamide Exposure in Wegeners Granulomatosis. The Journal of Rheumatology.https://jrheum.com/subscribers /08/01/11.htmlAbstract
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