Title: Alveolar Rhabdomyosarcoma Arising From Maxillary Antrum in a Adult: A Rare Case Report
Authors: Amod Kumar, Anju Singh, Sanjeet Kumar Singh, M.A. Muzaffar, Subhash Chandra Jha, Shahab Raza, Rakesh Kumar Singh
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.05
Rhabdomyosarcoma is one of the most common soft-tissue sarcomas in children under 15 years of age, and the head and neck is the principal location for childhood rhabdomyosarcoma; however head and neck rhabdomyosarcoma is rare in adults, occasionally occurs in nasal cavity and paranasal sinuses, it is rare at this site in adults. The typical subtypes of embryonal, alveolar and pleomorphic rhabdomyosarcoma are diagnosed histopathologically. The markers connoting simple myogenous or skeletal muscle differentiation has contributed tremendously to the diagnosis of even poorly differentiated rhabdomyosarcoma .The alveolar variant is more commonly seen in extremities and is very unusual in nasal and paranasal sinuses. Desmin and myogenin were highly positive while others were negative. Thus, a rare diagnosis of alveolar rhabdomyosarcoma arising from maxillary antrum was confirmed. We present a rare case of Alveolar rhabdomyosarcoma at unusual site in an adult. Keywords:Rhabdomyosarcoma, alveolar, adult, paranasal sinus 1. Rosai and Ackerman’s Surgical Pathology. 10th ed. 2011, pp. 2166-2171. 2. Enzinger and Weiss’s Soft tissue tumors. 4th ed. 2001, pp. 785-828. 3. Dias P, Chen B, Dilday B, Palmer H, Hosoi H, Singh S et al. Strong Immunostaining for Myogenin in Rhabdomyosarcoma Is Significantly Associated with Tumors of the Alveolar Subclass . Am J Pathol 2000; 156(2):399-408. 4. Jeong Hoon Lee, Mi Sook Lee, Byung Hee Lee, et al. Rhabdomyosarcoma of the head and neck in adults: MR and CT findings. AJNR Am J Neuroradiol 1996;17:1923-28. 5. Kumar S, Perlman E, C A Harris, Raffled M ,Tsokos M .Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues. Mod Pathol 2000;13(9):988–993 6. Nayar RC, Prudhomme F, Parise O Jr, Gandia D, Luboinski B, Schwaab G. Rhabdomyosarcoma of the head and neck in adults: a study of 26 patients. Laryngoscope 1993;103:1362-66. 7. Feldman BA. Rhabdomyosarcoma of the head and neck. Laryngoscope 1982;92:424-40. 8. Tsung-Han Wu, Jen Seng Huang, Hung-Ming Wang, Cheng-Hsu Wang, Kun-Yun Yeh. Long term survivors of adult rhabdomyosarcoma of maxillary sinus following multimodal therapy: Case reports and literature reviews. Chang Gung Med J 2010;33:466-471.Abstract
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