Title: Causes of death among people living with HIV/AIDS attending tertiary care hospital, Mandya, Karnataka, India

Authors: Dr Rekha.M.C, Dr Shivakumar.K.M, Dr G.M.Prakash, Dr Manju.B, Dr Suresh.C, Dr Ravikumar.M.B.

 DOI:  http://dx.doi.org/10.18535/jmscr/v3i9.03

Abstract

In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV) infected with access to HAART. To understand the recent temporal trends in acquired immunodeficiency syndrome (AIDS) mortality in the era of HAART, trends in causes of death among persons with AIDS, this study was taken up at MIMS hospital, Mandya. Karnataka, India. Among 200 patients From the ART center, we found that pulmonary tuberculosis was the commonest cause of death, 86 patients (43%), EPTB was present in 43 patients (21.5%), hepatitis in 16 patients (8%), suicide in 12 patients (6%), Bacterial pneumonia in 11 patients (5.5%), Bacterial infection in 8 patients (4%), Liver disease in 7 patients (3.5%), Accident in 5 patients (2.5%), Alcohol related in 5 patients (2.5%), Diarrhea in 4 patients (2%), Cardiovascular disease in 3 patients (1.5%). With increasing AIDS survival, still opportunistic infections top the list , non HIV related causes of death like suicide, accidents, alcohol related and cardiovascular disease constitute a smaller number of deaths.

Keywords:  HIV, Cause of death, CD4 count, Opportunistic infections.

References

1.      E.Martinez ; A Milinkovic et al.  Incidence and causes of death in HIV infected persons receiving highly active antiretro-viral therapy compared with estimates for the general population of similar age and from the same geographical area. HIV medicine 2007;8(4):251-258.

2.      Janice K Louie et al. “Trends in causes of death among persons with acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy, San Francisco, 1994-1998.

3.      Charotte Lewden et al. Causes of death. Among human immunodeficiency virus (HIV) infected adults in the era of protect antiretroviral therapy: emerging role of hepatitis and causes persistent role of AIDS International Journal of epidemiology ( 2005) 34 (1) 121-130.

4.      Richard L. Guerrant ,Dand H Walker, peter F Weller - “Tropical infection diseas-es”. Principles, pathogens and practice. 3rd edition. ELSEVIER Saunders 2011; 1046.

5.      Sharma S K, Auadi Mohan, Tamilarasu Kadhiravan. HIV-TB co-infection: Epide-miology, diagnosis & management. Indian J.med Res 121, April 2005, pp 550-567.

6.      Dominique Salmon-ceron, Charlotte Lewden, Phillippe Morlat, Sibylle Bevitacqua Eric Jougla, Fabrice Bonner er al. “ Liver disease as a major cause of death among HIV infected patients; role of hepatitis C and B viruses and alcohol. Journal of hepatology volume 42, issue 6, June 2005, pages 799-805.

7.      Autonio G Pacheco, Suely H Tuboi, Jose C Faul haber, Lee H Harrison, Mauro Schechter –“ paper # 1; increases in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in Brazil” PLOS one Jan 30, 2008-PLOS one 2008, 3 (1); e 1531.

8.      Anant  A Takalkar, G S Saiprasas, V.G.Prasad, Narendra S.Madhekar. (2012), study of opportunistic infections in HIV seropositive patients admitted to com-munity care centre (CCC), KIMS Narketp-ally. Biomedical research 23(1);139-142.

9.      Aruna  Aggarwal, Usha Arora, Renuka Bajaj, Kavita Kumari (2005) Clinic-microbiological  study in HIV seropositivity patients, Journal of Indian Academy Clinical Medicine 6(2), 142-145.

10.  Gangadhar Goud and K Ramesh (2014) opportunistic infections among HIV patients attending tertiary care hospital, Karnataka, India. Int. Journal current mic-robiology Applied science 3(4),824 829.

11. Kashinath .B.Kamble, K.Sneha and K Ramesh (2014) A descriptive study on clinical profile of patients with HIV in a tertiary care hospital, International Journal Current Research Academy. 2(10),137-143

Corresponding Author

Dr Rekha.M.C

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