Title: Primary Sjӧgren's Syndrome with Granulomatous Interstitial Nephritis
Authors: Walaa H. Mohamad, Ahmad B. Elden, Wessam Ismail, Mahmoud Abd El-Radi
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.50
Sjӧgren's syndrome (SS) is a systemic autoimmune disease affecting mainly the exocrine glands. Tubulo-interstitial nephritis (TIN) is the most predominant renal involvement with lymphocyte and plasma cells infiltration of the interstitium. We report a case of young female with SS presented withrenal tubular acidosis (RTA), polyradiculoneuropathy & proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. Granuloma formation is rarely seen in of SS. Keywords: Sjӧgren's syndrome, Granulomatous tubulo-interstitial nephritis 1. Daniels TE and Fox PC: Salivary and oral components of Sjogren's syndrome. Rheum Dis Cli North Am.1992; 18:571–89. 2. Greenspan J. S, Daniels T. E, Talal Nand Sylvester R. A: The histopathology of Sjogren's syndrome in labial salivary gland biopsies. Oral surgery, oral medicine, and oral pathology. 1974;37(2), 217-29. 3. Bossini N, Savoldi S, Franceschini F, Mombelloni S, Baronio M andCavazzana I: Clinical and morphological features of kidney involvement in primary Sjogren's syndrome. Nephrology, dialysis, and transplantation J. 2001; 16(12), 2328-336. 4. Lafitte C, Amoura Z, Cacoub P, Pradat-Diehl P, Picq C andSalachas F: Neurological complications of primary Sjogren's syndrome. Journal of neurology.2001; 248(7), 577-84. 5. Maripuri S, Grande JP, Osborn TG, Fervenza FC, Matteson EL, Donadio JV and Hogan MC:Renal involvement in primary Sjögren's syndrome: a clinicopathologic study.Clin J Am SocNephrol. 2009 Sep;4(9):1423-31. 6. Zandbelt MM, van den Hoogen FH, de Wilde PC, van den Berg PJ, Schneider HG and van de Putte LB: Reversibility of histological andimmunohistological abnormalities in sublabial salivary gland biopsyspecimens following treatment with corticosteroids in Sjogren’s syndrome.Ann Rheum Dis.2001;60:511–13. 7. Sonia Cristina de Magalhães Souza Fialho, Samuel Bergamaschi, Fabrício Souza Neves, Adriana Fontes Zimmermann, Gláucio Ricardo Werner de Castroand IvânioAlves Pereira:Mycophenolatemofetil in primary Sjogren’ssyndrome: a treatment option for agranulocytosis. Rev Bras Reumatol.2012;52(2):295-99. 8. Dean C. Preddie, Glen S. Markowitz, Jai Radhakrishnan, Thomas L. Nickolas, Vivette D. D’Agati, Joshua A. Schwimmer, Mark Gardenswartz, Raquel Rosen and Gerald B. Appel: MycophenolateMofetil for the Treatment of Interstitial Nephritis. Clin J Am SocNephrol. 2006; 718–22. Abstract
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