Title: Study on Thyroid Dysfunction in Patients Attending Rama Medical Collage Hospital & Research Centre, Kanpur (Uttar Pradesh)- A Hospital Based Study
Authors: Dr Pavan Kumar Sharma, Dr P. B. Jain, Dr P. Anand, Dr I. Chaudhary, Mr S. Sharma
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.10
Thyroid dysfunction is defined as the altered serum thyroid stimulation hormone (TSH) level with normal or altered thyroid hormones (tri-iodothyronine- T3 and thyroxine- T4). Decreased level of circulating blood TSH with increased levels of circulating T3 andT4 is called overt hyperthyroidism whereas decreased level of circulating blood TSH with normal levels of circulating T3 andT4 is called subclinical hyperthyroidism. Increased level of circulating blood TSH with decreased levels of circulating T3 andT4 is called overt hypothyroidism whereas increased level of circulating blood TSH with normal levels of circulating T3 andT4 is called subclinical hypothyroidism. A total 354 subjects were enrolled in this study out of these 265 were female and 89 were male. The subjects were classified according to thyroid status as euthyroidism, overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism and subclinical hypothyroidism by taking reference of thyroid function test. Total hypothyroidism includes overt hypothyroidism plus subclinical hypothyroidism and total hyperthyroidism represents overt hyperthyroidism plus subclinical hyperthyroidism. Overn ight fast venous blood was collected from the subjects attending RMCHRC, Kanpur. Thyroid function test panel (T3, T4 and TSH) were assayed by the Cobas e411 immunoassay analyzer and its test kits. The present study has revealed the prevalence of thyroid dysfunction typically hypothyroidism and subclinical hypothyroidism were higher in this region but the etiology of the disease remains unidentified. Moreover, the disease was preponderant in women and the people of all age-group. Our study was a hospital based study; it may not represent the whole population. But, the study has identified the burden of thyroid dysfunction in this locality and can be used as baseline data for future studies. KEY WORDS: T3, T4and TSH, Euthyroid and Thyroid dysfunction. 1. Peter PAS eds. Epidemiology of Thyroid dysfunction-hypothyroidism and hyperthyroididm. Thyroid International 2009; 2: 1-16 2. Ladenson Paul W. American thyroid association guide-lines for detection of thyroid dysfunction. Arch Intern Med. 2000; 160: 1573-1575. 3. Guyton AC, Hall JE.A Text Book of Medical Physiology. 11th edition; Elsevier publishers; 2006; pp 905-943. 4. Jameson LJ. Disorders of the Thyroid Gland. Available From: http://www.medical library.net/thyroid_therapy.html 5. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Wickham survey. ClinEndocrinol. 1977;7:481-93. 6. Danese MD, Powe NR, Swain CT, Ladenson PW. Screening for mildthyroid failure at the periodic health examination- A decision and cost effective analysis. JAMA 1996; 276: 285. 7. Staub JJ, Althaus BU, Engler H et al. Spectrum of sub-clinical and overt hypothyroidism: effect on thyrotro-pin, prolactin, and thyroid reserve and metabolic im-pact on peripheral target tissue. Am J Med 1992; 92: 631-642. 8. Ingbar SH, Wiwams RH. Text book of endocrinology. 7th Edn. 1985, pp 792. 9. Camargo RY, Tomimori EK, Neves SC, GS Rubio I, Galrao AL, Knobel M, etal.Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil. Eur J Endocrinol 2008;159: 293-299. 10. Yang F, Teng W, Shan Z, Guan H, Li Y, Jin Y, et al. Epidemiological survey on therelationship between different iodine intakes and the prevalence of hyperthyroidism.EurJEndocrinol 2002; 146: 613-618. 11. Abraham R, Murugan S V, Pukazhvanthen P and Sen S K. Thyroid disorders inwomen of puducherry. Indian Journal of Clinical Biochemistry, 2009 / 24 (1) 52-59. 12. AryalM,GyawaliP,RajbhandariN,AryalPPandey D R. A prevalence of thyroid dysfunction in Kathmandu University Hospital, Nepal. Biomedical Research 2010; 21 (4): 411-415 13. Ali M, Nouh, Ibrahim A. M. Eshnaf, and Mohamed A. Basher.Prevalence of thyroid dysfunction and its effect onserum lipid profiles in a murzok, Libya population.Thyroid Science 3(10):CLS1-6, 2008 www.ThyroidScience.com Clinical and Lab Studies. 14. Aminorroaya A, J anghorbani M, MasoudAmini M,Hovsepian S, Tabatabaei A,Fallah Z. The prevalence of thyroid dysfunction in an iodine-sufficient area in Iran.Arch Iranian Med 2009; 12 (3): 262 – 270262 Archives of Iranian Medicine, Volume 12, Number 3, May 2009 15. Menon VU, Sundaram KR, Unnikrishnan AG, Jayakumar RV, Nair V, Kumar H. High prevalence of undetected thyroid disorders in an iodine sufficient adult south Indian population. J Indian Med Assoc 2009;107:72-7. 16. Yu-shan M, Zhi-min L, Chang-xi C, Zhong-wei Z and Zhong-li H.Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employee’s-cohort. Chinese Medical Journal 2010;123(13):1673-1678 1673Abstract
References