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Category: Volume 3 Issue 11 November 2015
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Title: Comparison of Sublingual, Vaginal and Oral Misoprostol in Cervical Ripening Prior to 1st Trimester Surgical Abortion a Prospective Study

Authors:Dr Jagadevi S, Dr Anupama Suresh, Dr Priya Ballal

 DOI:  http://dx.doi.org/10.18535/jmscr/v3i11.19

Abstract

Aim: Comparison of sublingual, vaginal and oral misoprostol as a cervical ripening agent 4 hours prior to surgical abortion

Objective: To compare effectiveness and tolerability of misoprostol as cervical ripening agent in 1st trimester surgical abortion through different routes.

Materials And Methods: Hospital based prospective randomized study in which 144 women were divided into 3 groups sublingual, vaginal and oral group and single dose 400µg misoprostol was administered 4 hours prior to evacuation. Efficacy was assessed on the basis of dilation achieved and duration of procedure, the tolerability was evaluated based on the side effects.

Results: Cervical dilatation achieved in sublingual group was better than the other routes and had statistical significance. Duration of procedure was also lesser in sublingual group  compared to oral  and vaginal group. Side effects were seen in all groups, but vomiting being more common in oral group, nausea and uterine cramps more common  in vaginal group and loose motion was seen only in sublingual group.

Conclusion; Administration of misoprostol by sublingual route is better than the oral and  vaginal routes for cervical ripening.

Key words: cervical ripening, misoprostol, dilation, side effects, first trimester abortion

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Corresponding Author

Dr Jagadevi S

Junior Resident, Department of Obstetrics and Gynaecology (Lady Goschen Hospital)

Kasturba Medical College (A Constituent of Manipal University)

Mangalore, Karnataka - 575001, India