Title: Vitamin B12 deficiency leading to Depression
Authors: Dr Sneha Arya, Dr Sanjiv S. Kale, Dr Aparna Ramakrishnan
DOI: http://dx.doi.org/10.18535/jmscr/v3i12.47
Vitamin B12, also known as cobalamin is a water soluble vitamin, playing a key role in neuronal functions of the brain, nervous system and cellular metabolism especially DNA synthesis formation. Deficits in vitamin B12 have negative consequences on the developing brain during infancy and are associated with a greater risk of depression during adulthood. Keywords: Vitamin B12 ; childhood depression. 1. Herrmann W, Lorenzl S, Obeid R. review of the role of hyperhomocystenemia and B- vitamin deficiency in neurological and psychiatric disorders: current evidence and preliminary recommendations. Fortschr Neurol Psychiatry 2009; 75(9) 515-27. 2. Bottliglieri T, Laundy M, Crellin R, et all. Homocysteine ,folate, methylation and monoamine metabolism in depression. J NeurolNeurosurg Psychiatry 2000; 157 (5) : 715-21. 3. Mischoulan D, Burger JK, Spillmann MK, Worthington JJ, Fava M, Alpert JE. Anemia and macrocytosis in the prediction of serum folate and Vitamin B12 status and treatment outcome in major depress-ion. J Psychosom Res 2000; 49 (3) : 183-7. 4. Hintikka J, Tolmunen T, Tanskanen A, Viinamaki H. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry 2003; 3(1) : 17-8.Abstract
References