Title: Hysteroscopic Evaluation of Abnormal Uterine Bleeding- Vaginoscopic Approach

Authors: Major (Dr) Rahul Mahajan, Colonel (Dr) Prasad Lele, Brigadier (Dr) Manash Biswas

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i1.42

Abstract

Introduction: Abnormal uterine bleeding, a common but complicated clinical presentation accounting for almost 20% of gynecologic outpatient visits1, reported 25% of gynecologic surgeries.2Easily accomplished in an office setting with little or no analgesia or anesthesia, office hysteroscopy provides direct access to the uterine cavity giving an accurate diagnosis directing surgical or medical treatment for the specific pathology and may avoid the need for major surgery 

Aims & Objectives: Hysteroscopic evaluation of the cervical canal & uterine cavity in women with AUB to evaluate various causes and to perform diagnostic or therapeutic intervention whenever possible to reach the actual diagnosis and relieve the symptoms in office setting. 

Method: 100 cases diagnosed with various presentations of AUB in reproductive and postmenopausal group were evaluated prospectively by office hysteroscopy with vaginoscopy approach between Jan 2014 to Jun 2015 in tertiary care hosp of Pune (Maharashtra). Histopathology examination of endometrium and/or pelvic ultrasound was done in selective cases to reach a final diagnosis. 

Results: Office hysteroscopy was successfully carried out in 98 of 100 women, 42 % of these had normal cavity, 13% had fibroid, 12% had polyp, 7% had hyperplastic endometrium, 7% had adenomyosis, 3% foreign bodies, 7% intrauterine adhesions, 2% tubercular endometritis, 1 % retained products, 1 case of endometrial CA and 2 cases of uterine anomalies. 

Total 12 cases (12.24%) of AUB were treated in the same setting, including six cases of weak intrauterine adhesions, three cases each of small intrauterine polyps and three cases of foreign bodies, in two cases CuT thread was missing whereas the other woman having AUB was unaware about CuT inserted in her uterus long back.

Conclusion: Diagnostic hysteroscopy performed with vaginoscopy approach in an office setting with little discomfort to the patient, enabled the physician to search for organic intrauterine abnormalities and to select the proper form of therapy based on the findings reducing requirement of unnecessary surgical intervention in patients with normal cavity. A small proportion of patients were treated in the same setting for the underlying pathology to relieve the symptoms. With the invention of modern thin caliber, cordless and portable devices, office hysteroscopy will definitely be used as a first step in evaluation of AUB. 
Keywords: Abnormal uterine bleeding, Office hysteroscopy, Vaginoscopy, Menorrhagia, Polyp, Fibroid.

References

1.      Nicholson WK, Ellison SA, Grason H, Powe NR. Patterns of ambulatory care use for gynecologic conditions: a national study. Am J Obstet Gynecol2001;184:523-30.

2.      Nash S. Moawad, Estefania Santamaria, BS, Megan Johnson, Jonathan Shuster. Cost-Effectiveness of Office Hysteroscopy for Abnormal Uterine Bleeding, JSLS, DOI: 10.4293/JSLS.2014.00393, Source: PubMed

3.      Bettocchi S, Di Spiezio Sardo A, Ceci O, Nappi L, Guida M, Greco E, Pinto L, Camporiale AL, Nappi C. A new hysteroscopic technique for the preparation of partially intramural myomas in office setting (OPPIuM technique): A pilot study. J Minim Invasive Gynecol. 2009 Nov-Dec; 16(6):748-54.

4.      Thomas Ro¨mer, Andreas D. Ebert. Thomas Romer Diagnostic Hysteroscopy, 2nd edition, 2010, Walter de Gruyter GmbH & Co. KG, Berlin/New York.

5.      Liselotte Mettler, M. Parikh, Thoralf Schollmeyer. Diagnostic and Operative hysteroscopy,  Society of laparoscopic surgeon, Prevention and management of laparoendoscopic surgical complications 3rd edition, 2012, Chapter-42

6.      Goodman A. Abnormal genital tract bleeding. Clin Cornerstone 2000;3:25-35.

7.      Hill NC, Oppenheimer LW, Morton KE. The aetiology of vaginal bleeding in children. A 20-year review. Br J Obstet Gynaecol 1989;96:467-70.

8.      Livingstone M, Fraser IS. Mechanisms of abnormal uterine bleeding. Hum Reprod Update 2002;8:60-7.

9.      Lethaby A, Farquhar C, Sarkis A, Roberts H, JepsonR, Barlow D. Hormone replacement therapy in postmenopausal women: endometrial hyperplasiaand irregular bleeding. Cochrane Database Syst Rev2003;(4):CD000402.

10.  Speroff L, Glass RH, Kase NG. Clinical gynecologic endocrinology and infertility. 6th ed. Baltimore: Lippincott Williams & Wilkins, 1999:201-38,499,575-9.

11.  Shwayder JM. Pathophysiology of abnormal uterine bleeding. Obstet Gynecol Clin North Am 2000;27:219-34.

12.  Oriel KA, Schrager S. Abnormal uterine bleeding. Am Fam Physician 1999;60:1371-80.

13.  Malcolm G. Munro, Hilary O.D. Critchley, Michael S. Broader, Ian S. Fraser: For FIGO working group on menstrual disorder. FIGO classification system (PALM COEIN) for causes of abnormal uterine bleeding in non gravid women of reproductive age. Fertil Steril 2007; 87(3): 466-76,Hum Reprod 2007; 22(3): 635-43

14.  Apgar BS. Dysmenorrhea and dysfunctional uterine bleeding. Prim Care   1997;24:161-78.

15.  Goldstein SR, Zeltser I, Horan CK, Snyder JR, Schwartz LB. Ultrasonography-based triage for perimenopausal patients with abnormal uterine bleeding. Am J Obstet Gynecol 1997;177:102-8.

16.  ACOG practice bulletin no-28: Clinical management guidelines for obstetrician-gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001;96(6 suppl):1-11.

17.  Luca Mencaglia, Luiz Cavalcanti de Albuquerque neto, R. Alfonso arias alvarez. Manual of hysteroscopy, Diagnostic, Operative and Office hysteroscopy. Endopress 2013, Germany.

18.  Valle R, Glob. libr. women's med.,Hysteroscopy, Contact Hysteroscopy, and Microhysteroscopy. ISSN: 1756-2228) 2008; DOI 10.3843/ GLOWM. 10087

19.  Clark TJ, Mann CH, Shah N, Khan KS, Song F, Gupta JK. Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review. BJOG 2002;109:313-21.

20.  Dijkhuizen FP, Mol BW, Brolmann HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia:a meta-analysis. Cancer 2000;8:1765-72.

21.  Tabor A, Watt HC, Wald NJ. Endometrial thickness as a test for endometrial cancer in women with postmenopausal vaginal bleeding. Obstet Gynecol 2002;99:663-70.

22.  Medverd JR, Dubinsky TJ. Cost analysis model: US versus endometrial biopsy in evaluation of peri- and postmenopausal abnormal vaginal bleeding, Radiology 2002;222:619-27.

23.  Clark TJ, Voit D, Gupta JK, Hyde C, Song F, Khan KS. Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: a systematic quantitative review. JAMA 2002;288:1610-21.

24.  De Vries LD, Dijkhuizen FP, Mol BW, Brolmann HA, Moret E, Heintz AP. Comparison of transvaginal sonography, saline infusion sonography, and hysteroscopy in premenopausal women with abnormal uterine bleeding. J Clin Ultrasound 2000;28: 217-23.

25.  Krampl E, Bourne T, Hurlen-Solbakken H, Istre O. Transvaginal ultrasonography, sonohysterography and operative hysteroscopy for the evaluation of abnormal uterine bleeding. Acta Obstet Gynecol Scand 2001;80:616-22.

26.  Widrich T, Bradley LD, Mitchinson AR, Collins RL. Comparison of saline infusion sonography with office hysteroscopy for the evaluation of the endometrium. Am J Obstet Gynecol 1996;174: 1327-34.

27.  O’Connell LP, Fries MH, Zeringue E, Brehm W. Triage of abnormal postmenopausal bleeding: a comparison of endometrial biopsy and transvaginal sonohysterography versus fractional curettage with hysteroscopy. Am J Obstet Gynecol 1998;178:956-61.

28.  Mihm LM, Quick VA, Brumfield JA, Connors AF Jr, Finnerty JJ. The accuracy of endometrial biopsy and saline sonohysterography in the determination of the cause of abnormal uterine bleeding. Am J Obstet Gynecol 2002;186:858-60.

29.  Ben-Yehuda OM, Kim YB, Leuchter RS. Does hysteroscopy improve upon the sensitivity of dilatation and curettage in the diagnosis of endometrial hyperplasia or carcinoma? Gynecol Oncol 1998; 68:4-7.

30.  Tahir MM, Biqriqq MA, Browning JJ. A randomized controlled trial comparing transvaginal ultrasound, outpatient hysteroscopy and endometrial biopsy with inpatient hysteroscopy and curettage. Br J Obstet Gynaecol, 1999;106:1259–64.

31.  Gianninoto A, Morana C, Campione C. Diagnostic hysteroscopy in abnormal uterine bleeding. Five years experience. Mineva Ginecol. 2003;55:57–61

32.  Sciarra JJ, Valle RF. Hysteroscopy: a clinical experience with 320 patients. Am J Obstetet Gynecol. 1977;127:340–8.

33.  Smith-Bindman R, Kerlikowske K, Feldstein VA, Subak L, Scheidler J, Segal Ml. Endovaginal ultrasound to exclude endometrial cancer and other endometrial abnormalities. JAMA 1998;280: 1510-7.

34.  Stovall TG, Ling FW, Morgan PL. A prospective, randomized comparison of the Pipelle endometrial sampling device with the Novak curette. Am J Obstet Gynecol 1991;165(5 pt 1):1287-90.            

35.  Bettocchi S, Ceci O, Vicino M, Marello F, Impedovo L, Selvaggi L. Diagnostic inadequacy of dilatation and curettage. Fertil Steril 2001;75:803-5.

36.  Gimpelson RJ. Panoramic hysteroscopy with directed biopsies vs. dilatation and curettage for accurate diagnosis. J Reprod Med 1984;29:575-8.

37.  Fleischer AC, Wheeler LE, Lindsay I, Hendrix SI, Grabill S, Kravitz B. An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. Am J Obstet Gynecol 2001;184:70-5.

38.  Apgar BS, Greenberg G. Using progestins in clinical practice. Am Fam Physician 2000;62:1839-46, 1849- 50.

39.  DeVore GR, Owens O, Kase N. Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding—a double-blind randomized controlled study. Obstet Gynecol. 1982 Mar;59(3):285-91

40.  Bettochi S, Nappi L, Ceci O, et al. Office hysteroscopy. Obstetrics and gynecology clinics of North America: advances in laparoscopy and hysteroscopy techniques, Philadelphia: W.B. Saunders Company; 2004. p. 641–54.

41.  Schwarzler P, Concin H, Bosch H. An evaluation of sonohysterography and diagnostic hysteroscopy for assessment of intrauterine pathology. Ultrasound Obstet Gynecol. 1998;11: 337–42.

42.  Hamou JE. Microhysteroscopy: a new procedure and its original applications in gynecology. J Reprod Med1981;26:375-82

43.  Pasqualotto EB, Margossian H, Price LL. Accuracy of preoperative diagnostic tools and outcome of hysteroscopic manage-ment of menstrual dysfunction. J Am Assoc Gynecol Laparosc. 2000;7:201–9.

44.  Baggish MS, Barbot J. Contact hysteroscopy. Clin Obstet Gynecol. 1983;26:219–41.

45.  Bhattacharya BK. Hysteroscopy for gynaecologic diagnosis. J Obstet Gynecol India. 1992;42:373–5.

46.  Cicinelli E, Romano F, Anastasio PSl. Sonohysterography versus hysteroscopy in the diagnosis of endouterine polyps. Gynecol Obstet Invest. 1994;38:266–71.

47.  T P Medina, E C Font. Diagnostic and Operative Hysteroscopy,2nd edition,2011,Pub: JPBMP.

48.  Downes E, al Azawi F: How well do perimenopausal patients accept outpatient hysteroscopy? Visual analogue scoring of acceptability and pain in 100 women. Eur J Obstet Gynecol Teprod Biol 48:37, 1993.

49.  Wheeler JM, DeCherney AH: Office hysteroscopy. Obset Gynecol Clin North Am 15:29, 1988.

50.  Farquhar C, Ekeroma A, Furness S. A systematic review of transvaginal ultrasonography, sonohysterography and hysteroscopy for the investigation of abnormal uterine bleeding in premenopausal women. Acta Obstetricia et Gynecologica Scandinavica. 2003;82(6):493–504.

51.  Chaudhari KR, Parul Sathe. Role of diagnostic hysteroscopy in evaluation of abnormal uterine bleeding and its histopathological correlation  Int J             Reprod Contracept Obstet Gynecol. 2014 Sep;3(3):666-670, DOI:    10.       5455/2320 1770.ijrcog20140958

52.  S Bettochi, O Ceci, R,Di Venere, M.V. Pansini, A.Peliegrino, F.Marello and L.Nappi. Advanced office hysteroscopy without anesthesia: Analysis of 501 cases. Human reproduction Vol-17 No-9 pp 2435-2438,2002.

53.  Jyotsana, Kamlesh Manhas, Sudha Sharm, Role of Hysteroscopy and Laparoscopy in Evaluation of Abnormal Uterine Bleeding, JK science, Vol. 6 No. 1, January-March 2004.

54.  Guin Gita, Sandhu Surpreet Kaur, Lele Arvind, Khare Shashi. Hysteroscopic evaluation of AUB, The Journal of Obstetrics and Gynecology of India, (September–October 2011), 61(5):546–549,DOI:10.1007/s13224-011-0088-6.

55.  Van Dongen H,De Kroon CD,Jacobi CE,Trimbos JB,Jansen FW. Diagnostic hysteronscopy in abnormal uterine bleeding: a systematic             review and meta analysis. BJOG. 2007 Jun; 114(6):664-75.

Corresponding Author

Major (Dr) Rahul Mahajan

Resident, Dept of Obs & Gyn,

Armed Forces Medical College, Pune