Title: Role of Hemoperfusion in Phenytoin Poisoning
Authors: Dr Nilesh Bastewad, Dr Deelip Kadam, Dr Pramod Umarji, Dr Harshal Bhitkar, Dr Nilesh Palasdeokar
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.41
Suicidal ingestion of phenytoin can lead to severe neurological sequelae. Charcoal Hemoperfusion decreases phenytoin level. We present a lady with suicidal ingestion of phenytoin who responded to Charcoal Hemoperfusion. 1. Sen S, Ratnaraj N, Davies NA, Mookerjee RP, Cooper CE, Patsalos PN, et al. Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS). Epilepsia. 2003;44:265-7. 2. Miller MA, Crystal CS, Patel MM. Hemodialysis and hemoperfusion in a patient with an isolated phenytoin overdose. Am J Emerg Med. 2006;24:748-9. 3. Eyer F, Felgenhaueur N, Rudi P, Thurmel K, ZilKer T. Treatment of severe intravenous phenytoin overdose with hemodialysis and hemoperfusion. Med Sci Monit. 2008;14:145-8. 4. Hwang WJ, Tsai JJ. Acute phenytoin intoxication: Causes, symptoms, misdiagnosis and outcomes. Kaohsiung J Med Sci. 2004;20:580-5. 5. Gill MA, Kern JW, Kaneko J, McKeon J, Davis C. Phenytoin overdose. West J Med. 1978; 128:246-8. 6. Barth N, Alvan G, Borga O, Sjoqvist F. Two-fold interindividual variation in plasma protein binding of phenytoin in patients with epilepsy. Clin Pharmacokinet. 1976; 1: 444-52. 7. Kawasaki C, Nishi R, Uekihara S, Hyano S, Otagiri M. Charcoal hemoperfusion in the treatment of phenytoin overdose. Am J Kidney Dis. 2000;35:323-6. 8. Lowry JA, Vandover JC, Degreeff J, Scalzo AJ. Unusual presentation of iatrogenic phenytoin toxicity in a newborn. Int J Med Toxicol. 2004;4:26-9.Abstract
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