Title: New Onset Diabetes after Renal Transplantation (NODAT): Prevalence, Risk Factors and Treatment
Authors: Lakshminarayana GR, Sheetal LG, Anil M, Rajesh R, George K, Unni VN
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.30
Background:This study was conducted to assess the prevalence rate, risk factors and response to treatment of NODAT after renal transplantation. Methods:All consecutive non-diabetic renal transplant recipients (RTR) from 2005 to 2011; done at AIMS, Kochi, were included in the study. ADA criteria (2003) for NODAT was for its diagnosis. Results:The study group included 125 (M:101, F:24) RTRs with a mean age of 31.53 years, with a mean follow-up of 32.01 months after surgery. The prevalence rate of NODAT was 23%. Majority (80 %) of recipients with NODAT, had it within first 6 months after surgery. The prevalence rate of NODAT was higher males and those aged >40 years. The prevalence rate of NODAT was higher in those with family history of diabetes mellitus and pre-transplant impaired glucose levels.The prevalence rate of NODAT was higher with Tacrolimus based regimen and also those receiving methyl prednisolone as part of antirejection therapy. Majority (55 %) of those with NODAT had normal BMI. The prevalence of graft dysfunction was higher in those with NODAT. Conclusions: The prevalence rate of NODAT was 23%, with a peak incidence in initial 6 months after renal transplantation. The non-modifiable risk factors for NODAT were; age > 40 years, male gender, pre-transplant impaired glucose levels and family history of diabetes mellitus. The modifiable risk factors for NODAT were; immunosuppressive drugs (Tacrolimus > Cyclosporine A), antirejection therapy with Methyl prednisolone. The prevalence of graft dysfunction was higher in those with NODAT than those without NODAT. Key Words: NODAT, Renal transplantation, Modifiable risk factors, non-modifiable risk factors, 1. Victor MM, Ananda B, Patricia JE, Jorge AV, Erwin JA, Sherine EG, et al. Post-transplantation Diabetes. A systematic review of the literature. Diabetes Care 2002; 25:583–592. 2. Maskey R. New-Onset Diabetes After Transplant (NODAT). 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