Title: Clinical and Immunological Profile of Patients on Antiretroviral Therapy
Authors: Dr Harshal Bhitkar, Dr Meenakshi Bhattacharya, Dr Suhas Bendrikar, Dr Shaikh
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.29
Availability of antiretroviral therapy has changed the scenario of HIV endemic and now HIV disease has become a chronic manageable condition. Under NACP III nationwide free ART program was started. The purpose of this study was to document clinical and immunological profile of patients on ART attending ART centre OPD. The present retrospective study was conducted in the ART centre of a tertiary care hospital, Nanded which was started in April 2007. Amongst 2980 patients on ART under regular follow up in ART centre, oral candidiasis was the most common OI observed in 953 (31.97%) patients followed by enteritis in 709 (23.47%) and herpes zoster in 284 (9.6%) patients. Pulmonary tuberculosis in 566 (19.58%), tuberculous lymphadenopathy in 417(14.42%) and abdominal tuberculosis was found in 635(21.97%) patients. Median baseline CD4 count increased from 240 to 467 cells/cm over a period of 18 months. Mean adherence to ART was found to be 94.95% in the study population. Keywords- Clinical, immunological profile, Antiretroviral therapy. 1. NACO 2005 ungass India report.NACO 2007. about NACO. 2. Kumarasamy N., Solomon Suniti et al , Natural History of Human Immunodeficiency Virus Disease in Southern India. Clinical Infectious Disease Journal (2003) 36 (1): 79-85. 3. Ayodhya R.K. et al, Opportunistic infections (OIs) present in HIV-seropositive patients: a study. Journal of International AIDS Soc. 2010; 13(Suppl 4): P191. 4. GedluBeshah et al, Study of prevalence of opportunistic infections among HIV/AIDS patients in Addis Ababa public hospitals. Addis ababa university school of graduate studies .may 2011. 5. Idigbe E.O. et al,Profile of HIV/AIDS associated opportunistic infections in Nigeria: 1986-1999. 2005 Journalists Against AIDS (JAAIDS) Nigeria. 6. Bellamy Richard, S Sangeetha et al, AIDS-defining illnesses among patients with HIV in Singapore, 1985 to 2001: results from the Singapore HIV Observational Cohort Study (SHOCS). BMC Infectious Diseases 2004, 4:47. 7. Bachani D., Garg R. et al, Two-year treatment outcomes of patients enrolled in India’s national first-line antiretroviral therapy programme. the National medical journal of India vol. 23, no. 1, 2010. 8. Lawn Stephen D et alCD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa.BMC Infectious Diseases 2006, 6:59 ,1471-2334. 9. McKinnon LR, Kimani M, et al. (2010) Effect of Baseline HIV Disease Parameters on CD4+ T Cell Recovery After Antiretroviral Therapy Initiation in Kenyan Women. PLoS ONE 5(7): e11434. doi:10.1371/journal.pone.0011434.Abstract
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