Title: Protective effect of Apple Cider Vinegar on Stress Induced Gastric Ulcer
Authors: Hader Ibrahim Sakr, Mohamed Mansour Khalifa, Mohamed Al Sayed Saleh, Laila Ahmed Rashed, Akef Abdel Halim Khowiled
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.28
A gastric ulcer is a break in the normal gastric mucosa integrity that extends through the muscularis mucosa into the sub-mucosa or deeper. This work aimed to study the effect of chronic administration of vinegar on gastric acid secretion, and if this action has any effect on stress-induced ulcer in male albino rats. Study groups included 24 rats divided into 2 main groups (12 rats/group): pyloric ligation group (A) and water immersion-induced gastric ulceration group (as a form of stress) (B). We evaluated; free and total HCL secretion in group A, ulcer score, ulcer index, percentage ulcer protection, , eNOS enzyme activity, COX-2 enzyme activity, glutathione reductase gene expression, CCK gene expression and proton pump (H+/K+ ATPase) gene expression in group B. We revealed significant decrease in free and total acidity, ulcer score and index, COX-2 enzyme activity and Proton pump (H+/K+ ATPase) gene expression among vinegar fed rats compared with the results of the control group. 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